Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H19NO8 |
Molecular Weight | 281.2598 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
InChI
InChIKey=ZQTHOIGMSJMBLM-BUJSFMDZSA-N
InChI=1S/C10H19NO8/c1-11(2)3-6(13)19-4-5(12)7(14)8(15)9(16)10(17)18/h5,7-9,12,14-16H,3-4H2,1-2H3,(H,17,18)/t5-,7-,8+,9-/m1/s1
Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin. Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and “detoxifying” the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering bloodcholesterol levels; and assisting in hormone regulation. Since there is no standard identity for the chemicals in pangamic acid, how it might work is unknown. Although pangamic acid is also called vitamin B15, there is no research that shows it is required by the body, as the term “vitamin” would suggest. The United States Food and Drug Administration has recommended seizing any chemicals advertised as pangamic acid and restraining the importation and interstate shipment of pangamic acid on the grounds that pangamic acid and pangamic acid products are unsafe for use and have no known nutritional properties
Approval Year
Sample Use Guides
In Vivo Use Guide
Curator's Comment: A common amount of DMG (Pangamic acid) is is 50–100 mg. taken twice daily, usually with breakfast and dinner. http://www.vitamins-supplements.org/pangamic-acid.php
Improvement in speech in 12 of a group of 15 children diagnosed retarded after
the oral administration of 20 mg of vitamin B15 (Pangamic acid) three times daily.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26875568
Addition of 0.1 uM N, N-Dimethylglycine (DMG) (also known as vitamin B15 or
pangamic acid) and no DMG (+DMG and –DMG, respectively) to a culture medium on in vitro development of IVP bovine embryos was examined under
both 20% (20O2) an oxygen concentration of and 5% (5O2) oxygen concentrations. In vitro culture of IVP bovine embryos at the 8- to 16-cell stage was conducted using the culture medium either in the absence (control
group) or presence of 0.5 mM hydrogen peroxide (H2O2). In another
group, both H2O2 and 0.1 uM DMG were added to the culture medium. When DMG was added to the H2O2-containing medium, the blastocyst formation
rate improved significantly (P < 0.01) to a level (57.1%) equivalent to that obtained in the control group, demonstrating that
DMG exerted a strong antioxidant effect by counteracting exogenous
oxidative stress in embryos.
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20858-86-0
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C105565
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SUB14754MIG
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m8380
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MPQ53A9F5C
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7886
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PANGAMIC ACID
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MPQ53A9F5C
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DTXSID70883201
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45934203
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100000090571
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)