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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H19NO8
Molecular Weight 281.2598
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PANGAMIC ACID

SMILES

CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

InChI

InChIKey=ZQTHOIGMSJMBLM-BUJSFMDZSA-N
InChI=1S/C10H19NO8/c1-11(2)3-6(13)19-4-5(12)7(14)8(15)9(16)10(17)18/h5,7-9,12,14-16H,3-4H2,1-2H3,(H,17,18)/t5-,7-,8+,9-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H19NO8
Molecular Weight 281.2598
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin. Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and “detoxifying” the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering bloodcholesterol levels; and assisting in hormone regulation. Since there is no standard identity for the chemicals in pangamic acid, how it might work is unknown. Although pangamic acid is also called vitamin B15, there is no research that shows it is required by the body, as the term “vitamin” would suggest. The United States Food and Drug Administration has recommended seizing any chemicals advertised as pangamic acid and restraining the importation and interstate shipment of pangamic acid on the grounds that pangamic acid and pangamic acid products are unsafe for use and have no known nutritional properties

Originator

Curator's Comment: Pangamic acid was discovered, isolated, identified, and synthesized in the laboratory of E.T. Krebs, Sr., and E.T. Krebs, Jr., in San Francisco, California, in 1951.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Pharmacology and therapeutic role of a new biocatalase; pangamic acid or vitamin B15].
1957 Feb 15
[Clinical research on pangamic acid].
1957 Oct 17
[Pharmacological notes on pangamic acid].
1957 Oct 17
[Vitamin B15 (pangamic acid)].
1958 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: A common amount of DMG (Pangamic acid) is is 50–100 mg. taken twice daily, usually with breakfast and dinner. http://www.vitamins-supplements.org/pangamic-acid.php
Improvement in speech in 12 of a group of 15 children diagnosed retarded after the oral administration of 20 mg of vitamin B15 (Pangamic acid) three times daily.
Route of Administration: Oral
Addition of 0.1 uM N, N-Dimethylglycine (DMG) (also known as vitamin B15 or pangamic acid) and no DMG (+DMG and –DMG, respectively) to a culture medium on in vitro development of IVP bovine embryos was examined under both 20% (20O2) an oxygen concentration of and 5% (5O2) oxygen concentrations. In vitro culture of IVP bovine embryos at the 8- to 16-cell stage was conducted using the culture medium either in the absence (control group) or presence of 0.5 mM hydrogen peroxide (H2O2). In another group, both H2O2 and 0.1 uM DMG were added to the culture medium. When DMG was added to the H2O2-containing medium, the blastocyst formation rate improved significantly (P < 0.01) to a level (57.1%) equivalent to that obtained in the control group, demonstrating that DMG exerted a strong antioxidant effect by counteracting exogenous oxidative stress in embryos.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:39:19 UTC 2023
Edited
by admin
on Fri Dec 15 19:39:19 UTC 2023
Record UNII
MPQ53A9F5C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PANGAMIC ACID
MART.   MI   WHO-DD  
Common Name English
GLYCINE, N,N-DIMETHYL-, 6-ESTER WITH D-GLUCONIC ACID
Common Name English
VITAMIN B15
Common Name English
Pangamic acid [WHO-DD]
Common Name English
PANGAMIC ACID [MI]
Common Name English
D-GLUCONIC ACID, 6-ESTER WITH N,N-DIMETHYLGLYCINE
Common Name English
PANGAMIC ACID [MART.]
Common Name English
Code System Code Type Description
CAS
20858-86-0
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
MESH
C105565
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
EVMPD
SUB14754MIG
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
MERCK INDEX
m8380
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY Merck Index
FDA UNII
MPQ53A9F5C
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
RXCUI
7886
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY RxNorm
WIKIPEDIA
PANGAMIC ACID
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
DAILYMED
MPQ53A9F5C
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
EPA CompTox
DTXSID70883201
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
PUBCHEM
45934203
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
SMS_ID
100000090571
Created by admin on Fri Dec 15 19:39:19 UTC 2023 , Edited by admin on Fri Dec 15 19:39:19 UTC 2023
PRIMARY
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ACTIVE MOIETY