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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H18NO8.Na
Molecular Weight 303.242
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM PANGAMATE

SMILES

CN(C)CC(=O)OC[C@]([H])([C@]([H])([C@@]([H])([C@]([H])(C(=O)[O-])O)O)O)O.[Na+]

InChI

InChIKey=MKVDFFROCUECAJ-CKDSBIORSA-M
InChI=1S/C10H19NO8.Na/c1-11(2)3-6(13)19-4-5(12)7(14)8(15)9(16)10(17)18;/h5,7-9,12,14-16H,3-4H2,1-2H3,(H,17,18);/q;+1/p-1/t5-,7-,8+,9-;/m1./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C10H18NO8
Molecular Weight 280.2522
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Pangamic acid (6-O-(dimethylaminoacetyl)-D-gluconic acid) has been detected 1938 and described as a natural, universally occurring substance with multiple biological and medical functions. In this respect pangamic acid has been worldwide on the market since decades as a drug stimulating cellular respiration. In addition to the natural pangamic acid, diisopropylammonium dichloroacetate (DIPA), a synthetic product not found in biological material, is on the market requesting similar biological functions. Pangamic acid is the name given to a product originally claimed to contain D-gluconodimethyl aminoacetic acid, which was obtained from apricot kernels and later from rice bran. It is also referred to as vitamin B15, but pangamic acid is not generally recognized as a vitamin. Despite serious safety concerns, pangamic acid is used for improving exercise endurance; treating asthma and related diseases, skin conditions including eczema, lung problems, painful nerve and joint conditions, cancer, and arthritis; improving the oxygenation of the heart, brain, and other vital organs; and “detoxifying” the body. It is also used for treating alcoholism, hangovers, and fatigue; protecting against urban air pollutants; extending cell life; strengthening the immune system; lowering bloodcholesterol levels; and assisting in hormone regulation. Since there is no standard identity for the chemicals in pangamic acid, how it might work is unknown. Although pangamic acid is also called vitamin B15, there is no research that shows it is required by the body, as the term “vitamin” would suggest. The United States Food and Drug Administration has recommended seizing any chemicals advertised as pangamic acid and restraining the importation and interstate shipment of pangamic acid on the grounds that pangamic acid and pangamic acid products are unsafe for use and have no known nutritional properties

Originator

Curator's Comment:: Pangamic acid was discovered, isolated, identified, and synthesized in the laboratory of E.T. Krebs, Sr., and E.T. Krebs, Jr., in San Francisco, California, in 1951.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Clinical research on pangamic acid].
1957 Oct 17
[Effects of pangamic acid in persons with cerebral sclerotic vascular disease].
1957 Oct 17
[Pharmacological notes on pangamic acid].
1957 Oct 17
[Vitamin B15 (pangamic acid)].
1958 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: A common amount of DMG (Pangamic acid) is is 50–100 mg. taken twice daily, usually with breakfast and dinner. http://www.vitamins-supplements.org/pangamic-acid.php
Improvement in speech in 12 of a group of 15 children diagnosed retarded after the oral administration of 20 mg of vitamin B15 (Pangamic acid) three times daily.
Route of Administration: Oral
Addition of 0.1 uM N, N-Dimethylglycine (DMG) (also known as vitamin B15 or pangamic acid) and no DMG (+DMG and –DMG, respectively) to a culture medium on in vitro development of IVP bovine embryos was examined under both 20% (20O2) an oxygen concentration of and 5% (5O2) oxygen concentrations. In vitro culture of IVP bovine embryos at the 8- to 16-cell stage was conducted using the culture medium either in the absence (control group) or presence of 0.5 mM hydrogen peroxide (H2O2). In another group, both H2O2 and 0.1 uM DMG were added to the culture medium. When DMG was added to the H2O2-containing medium, the blastocyst formation rate improved significantly (P < 0.01) to a level (57.1%) equivalent to that obtained in the control group, demonstrating that DMG exerted a strong antioxidant effect by counteracting exogenous oxidative stress in embryos.
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:07:50 UTC 2021
Edited
by admin
on Sat Jun 26 08:07:50 UTC 2021
Record UNII
7M7487Z3L6
Record Status Validated (UNII)
Record Version
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Name Type Language
SODIUM PANGAMATE
WHO-DD  
Common Name English
PANGAMIC ACID, SODIUM SALT
Common Name English
PANGAMIC ACID SODIUM SALT
Common Name English
D-GLUCONIC ACID, 6-ESTER WITH N,N-DIMETHYLGLYCINE, MONOSODIUM SALT
Common Name English
VITAMIN B15 SODIUM
Common Name English
D-GLUCONIC ACID, 6-ESTER WITH N,N-DIMETHYLGLYCINE, SODIUM SALT
Common Name English
VITAMIN B15, SODIUM SALT
Common Name English
SODIUM PANGAMATE [WHO-DD]
Common Name English
Code System Code Type Description
EVMPD
SUB14753MIG
Created by admin on Sat Jun 26 08:07:50 UTC 2021 , Edited by admin on Sat Jun 26 08:07:50 UTC 2021
PRIMARY
CAS
6888-14-8
Created by admin on Sat Jun 26 08:07:50 UTC 2021 , Edited by admin on Sat Jun 26 08:07:50 UTC 2021
PRIMARY
PUBCHEM
45934202
Created by admin on Sat Jun 26 08:07:50 UTC 2021 , Edited by admin on Sat Jun 26 08:07:50 UTC 2021
PRIMARY
FDA UNII
7M7487Z3L6
Created by admin on Sat Jun 26 08:07:50 UTC 2021 , Edited by admin on Sat Jun 26 08:07:50 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY