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Description
Curator's Comment: description was created based on several sources, including: DOI: 10.1042/bj0280143 DOI: 10.1042/bj0280152 http://www.wikidoc.org/index.php/Glycerol_3-phosphate

Synthetic glycerophosphates have been known for many years and have been prepared in several ways. The acid may exist in two isomeric forms, alpha and beta. The L-a-acid is the naturally occurring form; the b-acid, present in hydrolyzates of lecithins from natural sources, arises from migration of the phosphoryl group from the a-carbon atom. Dehydrogenation of L-glycerol 3-phosphate produces Dihydroxyacetone phosphate and is part of the entry of glycerol (sourced from triglycerides) into the glycolytic pathway.

CNS Activity

Originator

Grimbert, L.|Bailly, O.
4
Curator's Comment: alpha-glycerophosphoric acid has long been known as a component of the lecithins and cephalins and may in a sense be looked on as a monoglyceride, the situation is much more favorable. Because of its great stability it has been possible for several workers to separate it from various phosphatides and free it from its accompanying beta-isomer. http://www.jbc.org/content/128/2/491.short

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8429
KABIVEN

Approved Use

It is indicated as a source of calories, protein, electrolytes and essential fatty acids for adult patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

Launch Date

2014
PubMed

PubMed

TitleDatePubMed
alpha-Glycerophosphoric acid and brain metabolism.
1936 Jan
[Pharmacology of glycerophosphoric acid. II. Differences in the biological action of the alpha and beta isomers in combination with thiamine or cocarboxylase].
1955 Dec 1
[IN VITRO EFFECT OF ALPHA GLYCEROPHOSPHATE ON RELEASE OF NON-ESTERIFIED FATTY ACIDS FROM ADIPOSE TISSUE].
1965 Jun
Patents

Patents

IT 460219
4

Sample Use Guides

In Vivo Use Guide
19 to 38 mL/kg/day. The maximum infusion rate is 2.6 mL/kg/hour. Recommended infusion period is 12 to 24 hours.
Route of Administration: Intravenous
In Vitro Use Guide
Maximal ATP production in the presence of Ca2+ (200 nM) is obtained at 10 mM L-glycerol 3-phosphate in intact mitochondria from pancreatic B-cells.
Name Type Language
SODIUM GLYCEROPHOSPHATE
DASH   USAN   VANDF  
USAN   INCI  
Official Name English
SODIUM GLYCEROPHOSPHATE [ORANGE BOOK]
Common Name English
GLYCEROL PHOSPHATE DISODIUM SALT HYDRATE
Common Name English
SODIUM GLYCEROPHOSPHATE [USAN]
Common Name English
GLYCEROPHOSPHATE DISODIUM SALT HYDRATE
Common Name English
SODIUM GLYCEROPHOSPHATE [VANDF]
Common Name English
1,2,3-PROPANETRIOL, MONO(DIHYDROGEN PHOSPHATE), DISODIUM SALT, HYDRATE
Systematic Name English
SODIUM GLYCEROPHOSPHATE HYDRATE
Common Name English
Classification Tree Code System Code
DSLD 4342 (Number of products:27)
Created by admin on Sat Dec 16 20:08:48 GMT 2023 , Edited by admin on Sat Dec 16 20:08:48 GMT 2023
NCI_THESAURUS C29730
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WHO-ATC B05XA14
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WHO-VATC QB05XA14
Created by admin on Sat Dec 16 20:08:48 GMT 2023 , Edited by admin on Sat Dec 16 20:08:48 GMT 2023
Code System Code Type Description
DRUG BANK
DB09561
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PRIMARY
FDA UNII
RCS9EQ01V4
Created by admin on Sat Dec 16 20:08:48 GMT 2023 , Edited by admin on Sat Dec 16 20:08:48 GMT 2023
PRIMARY
DRUG CENTRAL
1318
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PRIMARY
RXCUI
1595589
Created by admin on Sat Dec 16 20:08:48 GMT 2023 , Edited by admin on Sat Dec 16 20:08:48 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL3040581
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PRIMARY
CAS
55073-41-1
Created by admin on Sat Dec 16 20:08:47 GMT 2023 , Edited by admin on Sat Dec 16 20:08:47 GMT 2023
PRIMARY
DAILYMED
RCS9EQ01V4
Created by admin on Sat Dec 16 20:08:47 GMT 2023 , Edited by admin on Sat Dec 16 20:08:47 GMT 2023
PRIMARY
USAN
YY-144
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PRIMARY
NCI_THESAURUS
C120561
Created by admin on Sat Dec 16 20:08:48 GMT 2023 , Edited by admin on Sat Dec 16 20:08:48 GMT 2023
PRIMARY
EVMPD
SUB15289MIG
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PRIMARY
EVMPD
SUB90005
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PRIMARY
All of the following components must be present:
Structure of SODIUM 2-GLYCEROPHOSPHATE PENTAHYDRATE
Structure of SODIUM 1-GLYCEROPHOSPHATE HEXAHYDRATE
Definition References
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NCATS
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