SODIUM GLYCEROPHOSPHATE

First marketed in 1921

Description
Sources: http://www.drugfuture.com/chemdata/Glycerophosphoric-Acid.html
Curator's Comment: description was created based on several sources, including: DOI: 10.1042/bj0280143 DOI: 10.1042/bj0280152 http://www.wikidoc.org/index.php/Glycerol_3-phosphate

Synthetic glycerophosphates have been known for many years and have been prepared in several ways. The acid may exist in two isomeric forms, alpha and beta. The L-a-acid is the naturally occurring form; the b-acid, present in hydrolyzates of lecithins from natural sources, arises from migration of the phosphoryl group from the a-carbon atom. Dehydrogenation of L-glycerol 3-phosphate produces Dihydroxyacetone phosphate and is part of the entry of glycerol (sourced from triglycerides) into the glycolytic pathway.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
glycerol-3-phosphate dehydrogenase 1 4 Target ID: 2819.0 Gene Symbol: GPD1 Sources: http://www.genome.jp/dbget-bin/www_bget?enzyme+1.1.1.8 \| https://www.ncbi.nlm.nih.gov/pubmed/490056	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Essential fatty acid deficiency or negative nitrogen balance 4 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/200656s001lbl.pdf	Preventing		Approved 8583	KABIVEN Approved Use It is indicated as a source of calories, protein, electrolytes and essential fatty acids for adult patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. Launch Date 2014

C_max

Value	Dose	Co-administered	Analyte	Population
2.87 mM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21986180/	80 mmol single, intravenous dose: 80 mmol route of administration: Intravenous experiment type: SINGLE co-administered:		PHOSPHATE ION serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
38.7 mM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21986180/	80 mmol single, intravenous dose: 80 mmol route of administration: Intravenous experiment type: SINGLE co-administered:		PHOSPHATE ION serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.06 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21986180/	80 mmol single, intravenous dose: 80 mmol route of administration: Intravenous experiment type: SINGLE co-administered:		PHOSPHATE ION serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
[IN VITRO EFFECT OF ALPHA GLYCEROPHOSPHATE ON RELEASE OF NON-ESTERIFIED FATTY ACIDS FROM ADIPOSE TISSUE].	1965-06	14347297
[Pharmacology of glycerophosphoric acid. II. Differences in the biological action of the alpha and beta isomers in combination with thiamine or cocarboxylase].	1955-12-01	13314697
alpha-Glycerophosphoric acid and brain metabolism.	1936-01	16745990

Patents

Sample Use Guides

In Vivo Use Guide

19 to 38 mL/kg/day. The maximum infusion rate is 2.6 mL/kg/hour. Recommended infusion period is 12 to 24 hours.

Route of Administration: Intravenous

In Vitro Use Guide

Maximal ATP production in the presence of Ca2+ (200 nM) is obtained at 10 mM L-glycerol 3-phosphate in intact mitochondria from pancreatic B-cells.

Name

Type

Language

GLYCEROL PHOSPHATE DISODIUM SALT HYDRATE

Preferred Name

English

SODIUM GLYCEROPHOSPHATE

Official Name

English

SODIUM GLYCEROPHOSPHATE [ORANGE BOOK]

Common Name

English

Sodium glycerophosphate hydrate [WHO-DD]

Common Name

English

SODIUM GLYCEROPHOSPHATE [USAN]

Common Name

English

GLYCEROPHOSPHATE DISODIUM SALT HYDRATE

Common Name

English

SODIUM GLYCEROPHOSPHATE [VANDF]

Common Name

English

1,2,3-PROPANETRIOL, MONO(DIHYDROGEN PHOSPHATE), DISODIUM SALT, HYDRATE

Systematic Name

English

SODIUM GLYCEROPHOSPHATE HYDRATE

Common Name

English

Classification Tree Code System Code

DSLD

4342 (Number of products:27)