U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C3H7O6P.2Na.5H2O
Molecular Weight 306.1138
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM 2-GLYCEROPHOSPHATE PENTAHYDRATE

SMILES

O.O.O.O.O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

InChIKey=PEMUISUYOHQFQH-UHFFFAOYSA-L
InChI=1S/C3H9O6P.2Na.5H2O/c4-1-3(2-5)9-10(6,7)8;;;;;;;/h3-5H,1-2H2,(H2,6,7,8);;;5*1H2/q;2*+1;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C3H9O6P
Molecular Weight 172.0737
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sodium glycerol 2-phosphate (Disodium beta-glycerophosphate) is used for the preparation of thermo-sensitive chitosan hydrogen as a scaffold to construct tissue engineered injectable nucleus pulposus (NP). Since Sodium glycerol 2-phosphate (6 g/day) reduced the lithogenic index of bile in human subjects with cholesterol gallstones in a short-term study and facilitated dissolution of cholesterol gallstones in mice, Sodium glycerol 2-phosphate may have potential to help dissolve cholesterol gallstones in man. Sodium glycerol 2-phosphate is an alkaline phosphate inhibitor. Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.

Originator

Sources: DOI: 10.1002/hlca.6602801220

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Glycophos

Approved Use

Glycophos is indicated in adult patients and infants as a supplement in intravenous nutrition to meet the requirements of phosphate.
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Enhancing effect of daidzein on the differentiation and mineralization in mouse osteoblast-like MC3T3-E1 cells.
2006 Aug
Antibacterial properties of Ag (or Pt)-containing calcium phosphate coatings formed by micro-arc oxidation.
2009 Jan
[Comparison study on injectable tissue engineered nucleus pulposus constructed by different cells and chitosan hydrogel].
2010 Jul
Taurine suppresses osteoblastic differentiation of aortic valve interstitial cells induced by beta-glycerophosphate disodium, dexamethasone and ascorbic acid via the ERK pathway.
2012 Oct
The extracellular matrix protein Edil3 stimulates osteoblast differentiation through the integrin α5β1/ERK/Runx2 pathway.
2017
Patents

Sample Use Guides

Dose Adults: The recommended dosage is individual. The recommended daily dosage of phosphate during intravenous nutrition would normally be 10-20 mmol. This can be met by using 10-20 mL of GLYCOPHOS (Sodium glycerophosphate pentahydrate) added to the infusion solution or to the admixture for which compatibility has been proved. Children, Infants and Neonates: The recommended dosage is individual. The recommended dose for children, infants and neonates is 1.0-1.5 mmol/kg body weight/day. Method of administration Intravenous Infusion. GLYCOPHOS must not be given undiluted. The infusion time should not be less than 8 hours.
Route of Administration: Intravenous
In Vitro Use Guide
Medium supplementation with beta-GP (Sodium 2-glycerophosphate) should not exceed 2 mM.
Substance Class Chemical
Created
by admin
on Thu Jul 06 16:19:09 UTC 2023
Edited
by admin
on Thu Jul 06 16:19:09 UTC 2023
Record UNII
5JIY5MMX0E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM 2-GLYCEROPHOSPHATE PENTAHYDRATE
Common Name English
1,2,3-PROPANETRIOL, 2-(DIHYDROGEN PHOSPHATE), DISODIUM SALT, PENTAHYDRATE
Common Name English
SODIUM .BETA.-GLYCEROPHOSPHATE PENTAHYDRATE
Common Name English
1,2,3-PROPANETRIOL, 2-(DIHYDROGEN PHOSPHATE), SODIUM SALT, HYDRATE (1:2:5)
Systematic Name English
GLYCEROL, 2-(DIHYDROGEN PHOSPHATE), DISODIUM SALT, PENTAHYDRATE
Common Name English
Code System Code Type Description
PUBCHEM
2735049
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
PRIMARY
CAS
154804-51-0
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
5JIY5MMX0E
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
PRIMARY
CAS
13408-09-8
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
PRIMARY
EPA CompTox
DTXSID60158536
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
PRIMARY
CAS
69881-75-0
Created by admin on Thu Jul 06 16:19:09 UTC 2023 , Edited by admin on Thu Jul 06 16:19:09 UTC 2023
ALTERNATIVE
Related Record Type Details
ANHYDROUS->SOLVATE