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Details

Stereochemistry ACHIRAL
Molecular Formula C3H7O6P.2Na
Molecular Weight 216.0374
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM 2-GLYCEROPHOSPHATE

SMILES

[Na+].[Na+].OCC(CO)OP([O-])([O-])=O

InChI

InChIKey=AVPCPPOOQICIRJ-UHFFFAOYSA-L
InChI=1S/C3H9O6P.2Na/c4-1-3(2-5)9-10(6,7)8;;/h3-5H,1-2H2,(H2,6,7,8);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C3H7O6P
Molecular Weight 170.0578
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Sodium glycerol 2-phosphate (Disodium beta-glycerophosphate) is used for the preparation of thermo-sensitive chitosan hydrogen as a scaffold to construct tissue engineered injectable nucleus pulposus (NP). Since Sodium glycerol 2-phosphate (6 g/day) reduced the lithogenic index of bile in human subjects with cholesterol gallstones in a short-term study and facilitated dissolution of cholesterol gallstones in mice, Sodium glycerol 2-phosphate may have potential to help dissolve cholesterol gallstones in man. Sodium glycerol 2-phosphate is an alkaline phosphate inhibitor. Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.

Originator

Sources: DOI: 10.1002/hlca.6602801220

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Glycophos

Approved Use

Glycophos is indicated in adult patients and infants as a supplement in intravenous nutrition to meet the requirements of phosphate.
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Bone regeneration by grafting of cultured human bone.
2004 May-Jun
Patents

Sample Use Guides

Dose Adults: The recommended dosage is individual. The recommended daily dosage of phosphate during intravenous nutrition would normally be 10-20 mmol. This can be met by using 10-20 mL of GLYCOPHOS (Sodium glycerophosphate pentahydrate) added to the infusion solution or to the admixture for which compatibility has been proved. Children, Infants and Neonates: The recommended dosage is individual. The recommended dose for children, infants and neonates is 1.0-1.5 mmol/kg body weight/day. Method of administration Intravenous Infusion. GLYCOPHOS must not be given undiluted. The infusion time should not be less than 8 hours.
Route of Administration: Intravenous
In Vitro Use Guide
Medium supplementation with beta-GP (Sodium 2-glycerophosphate) should not exceed 2 mM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:53:31 UTC 2023
Edited
by admin
on Fri Dec 15 15:53:31 UTC 2023
Record UNII
518FQS69A0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM 2-GLYCEROPHOSPHATE
Common Name English
1,2,3-PROPANETRIOL, 2-(DIHYDROGEN PHOSPHATE), SODIUM SALT (1:2)
Common Name English
1,2,3-PROPANETRIOL, 2-(DIHYDROGEN PHOSPHATE), DISODIUM SALT
Common Name English
.BETA.-GLYCEROPHOSPHATE DISODIUM
Common Name English
.BETA.-PHOSPHOGLYCEROL SODIUM
Common Name English
Code System Code Type Description
CAS
819-83-0
Created by admin on Fri Dec 15 15:53:31 UTC 2023 , Edited by admin on Fri Dec 15 15:53:31 UTC 2023
PRIMARY
PUBCHEM
4531952
Created by admin on Fri Dec 15 15:53:31 UTC 2023 , Edited by admin on Fri Dec 15 15:53:31 UTC 2023
PRIMARY
ECHA (EC/EINECS)
212-464-3
Created by admin on Fri Dec 15 15:53:31 UTC 2023 , Edited by admin on Fri Dec 15 15:53:31 UTC 2023
PRIMARY
FDA UNII
518FQS69A0
Created by admin on Fri Dec 15 15:53:31 UTC 2023 , Edited by admin on Fri Dec 15 15:53:31 UTC 2023
PRIMARY
EPA CompTox
DTXSID301002290
Created by admin on Fri Dec 15 15:53:31 UTC 2023 , Edited by admin on Fri Dec 15 15:53:31 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS