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Restrict the search for
icosapent ethyl
to a specific field?
Class (Stereo):
CHEMICAL (ACHIRAL)
Etoprindole is an antiinflammatory agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Cinfenine is diphenylmethoxyethylamine derivative that acts as antidepressant in some animal models.
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
INN:sprodiamide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Sprodiamide is a nonionic paramagnetic dysprosium chelate agent patented by Salutar, Inc.as diagnostic imaging contrast media. Compare with gadolinium-based agents Sprodiamide shows a stronger T2 effect and negligible T1 effect. This property makes Sprodiamide useful for blood volume imaging. In a preclinical model of reperfused ischemia of the rat intestine administration of Sprodiamide improved the contrast between the normal and ischemic intestine on T2-weighted images, and administration of both gadodiamide and Sprodiamide improved the contrast on T1- and T2-weighted images.
Class (Stereo):
CHEMICAL (RACEMIC)
Brifentanii, a potent narcotic analgesic structurally similar to alfentanil, that was studied in clinical trials in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable itching and respiratory depression. Side effects of Brifentanii are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Eterobarb (Antilon) is a barbiturate derivative. It is an effective anticonvulsant as demonstrated
in animal and clinical studies. Eterobarb possesses a unique and clinically intriguing
feature-at therapeutically effective blood levels, the hypnotic side effects usually associated
with barbiturates appear absent. Though effective
against both electrically and chemically induced
seizures in mice and rats, virtually no hypnotic effects were
noted except at lethal doses. Double-blind
cross-over studies have confirmed the anticonvulsant
efficacy of eterobarb and
several phase II and phase Ill studies show eterobarb
to be an effective anticonvulsant with less
hypnotic activity when compared with phenobarbital.
Eterobarb had been NDA filed for the treatment of epilepsy in the US, UK, Switzerland and Canada. However, this research has been discontinued. The compound was originated by Colgate Palmolive, then licensed to MacroChem.
Status:
Investigational
Source:
NCT00880412: Phase 2 Interventional Completed Alzheimer's Disease
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Etazolate (EHT-0202) is a selective, positive GABAA receptor modulator has completed phase II clinical trials in patients with Alzheimer's disease. It is also a selective phosphodiesterase-4 inhibitor that is specific for cAMP. Etazolate showed anxiolytic and antidepressant activity and could be useful in managing post-traumatic stress disorder.
Status:
Investigational
Source:
NCT02264041: Phase 1 Interventional Completed Healthy
(2004)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cilobradine is an Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker patented by a pharmaceutical company Boehringer Ingelheim G.m.b.H. for sinus tachycardia treatment. In clinical trials Cilobradine decrease Heart rate. Chronically increased heart rate (HR) is a risk factor for mortality and morbidity with adverse consequences on vascular function, atherogenesis, myocardial ischemia, myocardial energetics and left the ventricular function. Heart rate response was found to be concentration-dependent and appeared with a significant delay with respect to the time course of cilobradine in plasma.
Status:
Investigational
Source:
NCT01483833: Phase 2 Interventional Completed Hemorrhoids
(2001)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Indocate is indole derivative and monoamine oxidase inhibitor with peripheral antiserotonin properties.
