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Details

Stereochemistry ACHIRAL
Molecular Formula C14H19N5O2
Molecular Weight 289.333
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETAZOLATE

SMILES

CCOC(=O)C1=CN=C2N(CC)N=CC2=C1NN=C(C)C

InChI

InChIKey=OPQRBXUBWHDHPQ-UHFFFAOYSA-N
InChI=1S/C14H19N5O2/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2/h7-8H,5-6H2,1-4H3,(H,15,18)

HIDE SMILES / InChI

Molecular Formula C14H19N5O2
Molecular Weight 289.333
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Etazolate (EHT-0202) is a selective, positive GABAA receptor modulator has completed phase II clinical trials in patients with Alzheimer's disease. It is also a selective phosphodiesterase-4 inhibitor that is specific for cAMP. Etazolate showed anxiolytic and antidepressant activity and could be useful in managing post-traumatic stress disorder.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

2 capsules of study treatment (capsules of EHT0202 (ETAZOLATE) 40mg and or 80mg and/or placebo) are taken twice a day during breakfast and dinner over a 3-month treatment period.
Route of Administration: Oral
Etazolate (20 nM-2 microM) dose-dependently protected rat cortical neurons against Abeta-induced toxicity. The neuroprotective effects of etazolate were fully blocked by GABA(A) receptor antagonists indicating that this neuroprotection was due to GABA(A) receptor signalling
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:53:25 GMT 2023
Edited
by admin
on Sat Dec 16 17:53:25 GMT 2023
Record UNII
I89Y79062L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETAZOLATE
INN  
INN  
Official Name English
etazolate [INN]
Common Name English
1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLIC ACID, 1-ETHYL-4-((1-METHYLETHYLIDENE)HYDRAZINO)-, ETHYL ESTER
Common Name English
ETHYL 1-ETHYL-4-(ISOPROPYLIDENEHYDRAZINO)-1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLATE
Systematic Name English
EHT-0202
Code English
Classification Tree Code System Code
NCI_THESAURUS C28197
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
Code System Code Type Description
PUBCHEM
3277
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID4048434
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
CHEBI
138502
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL356388
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
SMS_ID
100000082372
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
INN
3736
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
WIKIPEDIA
Etazolate
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
CAS
51022-77-6
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
FDA UNII
I89Y79062L
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
EVMPD
SUB07267MIG
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
NCI_THESAURUS
C73334
Created by admin on Sat Dec 16 17:53:26 GMT 2023 , Edited by admin on Sat Dec 16 17:53:26 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
TARGET -> INHIBITOR
TARGET -> INHIBITOR
TARGET -> ACTIVATOR
Related Record Type Details
ACTIVE MOIETY