U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:42:57 GMT 2023
Edited
by admin
on Sat Dec 16 11:42:57 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
Y154T023U0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ADENOSINE RECEPTOR A2A
Common Name English
A2A
Common Name English
ADORA2
Common Name English
ADENOSINE A2A RECEPTOR
Common Name English
Code System Code Type Description
FDA UNII
Y154T023U0
Created by admin on Sat Dec 16 11:43:00 GMT 2023 , Edited by admin on Sat Dec 16 11:43:00 GMT 2023
PRIMARY
PHAROS
P29274
Created by admin on Sat Dec 16 11:43:00 GMT 2023 , Edited by admin on Sat Dec 16 11:43:00 GMT 2023
PRIMARY
UNIPROT
P29274
Created by admin on Sat Dec 16 11:43:00 GMT 2023 , Edited by admin on Sat Dec 16 11:43:00 GMT 2023
PRIMARY
From To
1_71 1_159
1_74 1_146
1_77 1_166
1_259 1_262
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_154
Related Record Type Details
AGONIST -> TARGET
BINDING
Kd
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
AGONIST -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Approximately 1000-fold more selective over other ARs.
Ki
INHIBITOR -> TARGET
Ki
INHIBITOR -> TARGET
Highly selective over hA2B Ki = 1110 nM.
Ki
INHIBITOR -> TARGET
ANTAGONIST
IC50
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
ANTAGONIST
Ki
AGONIST -> TARGET
BINDING
IC50
RADIOLIGAND->TARGET
BINDING
Kd
INHIBITOR -> TARGET
Ki
WEAK AGONIST->OFF TARGET
Rat brain receptor
BINDING
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
Ki
INHIBITOR -> TARGET
BINDING
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
selective antagonsist
Ki
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
IC50
INHIBITOR -> TARGET
Showed high selectivity over other adenosine receptors.
Ki
WEAK INHIBITOR->TARGET
Nonselective adenosine receptor antagonist. May be responsible for pain relief.
Ki
AGONIST -> TARGET
INHIBITOR -> TARGET
Kb actually
Kd
RADIOLIGAND->TARGET
Kd
AGONIST -> TARGET
INVERSE AGONIST->TARGET
EC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ANTAGONIST
Ki
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL