SPRODIAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H26N5O8.Dy
Molecular Weight	578.906
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Dy+3].CNC(=O)CN(CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O)CC([O-])=O

InChI

InChIKey=ABWHOEHSTSEVRD-UHFFFAOYSA-K

InChI=1S/C16H29N5O8.Dy/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3

HIDE SMILES / InChI

Molecular Formula	Dy
Molecular Weight	162.5
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H26N5O8
Molecular Weight	416.4063
Charge	-3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9170037 | https://www.ncbi.nlm.nih.gov/pubmed/8123724 | https://www.ncbi.nlm.nih.gov/pubmed/9040868

Sprodiamide is a nonionic paramagnetic dysprosium chelate agent patented by Salutar, Inc.as diagnostic imaging contrast media. Compare with gadolinium-based agents Sprodiamide shows a stronger T2 effect and negligible T1 effect. This property makes Sprodiamide useful for blood volume imaging. In a preclinical model of reperfused ischemia of the rat intestine administration of Sprodiamide improved the contrast between the normal and ischemic intestine on T2-weighted images, and administration of both gadodiamide and Sprodiamide improved the contrast on T1- and T2-weighted images.

Originator

Approval Year

PubMed

Title	Date	PubMed
Detection of reperfused ischemia of the rat intestine: value of magnetic resonance imaging with small-molecular-weight dysprosium and gadolinium chelates.	1997-01	9040868

Patents

Sample Use Guides

In Vivo Use Guide

0.1, 0.2, and 0.3 mmol/kg, at rates of 2 ml/second and 5 ml/second

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:45:30 GMT 2025` Edited by `admin` on `Wed Apr 02 09:45:30 GMT 2025`
Record UNII	0E6DA2DHBE
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

sprodiamide [INN]

Preferred Name

English

SPRODIAMIDE

Official Name

English

S-043

Code

English

DYDTPA-BMA

Code

English

DYSPROSIUM, (5,8-BIS(CARBOXYMETHYL)-11-(2-(METHYLAMINO)-2-OXOETHYL)-3-OXO-2,5,8,11-TETRAAZATRIDECAN-13-OATO(3-))-

Common Name

English

SPRODIAMIDE ANHYDROUS

Common Name

English

Sprodiamide [WHO-DD]

Common Name

English

SPRODIAMIDE [USAN]

Common Name

English

(N,N-BIS(2-((CARBOXYMETHYL)((METHYLCARBAMOYL)METHYL)AMINO)ETHYL)GLYCINATO(3-))DYSPROSIUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C390