Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H20N2O5 |
Molecular Weight | 320.3404 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1(C(=O)N(COC)C(=O)N(COC)C1=O)C2=CC=CC=C2
InChI
InChIKey=DACOQFZGGLCXMA-UHFFFAOYSA-N
InChI=1S/C16H20N2O5/c1-4-16(12-8-6-5-7-9-12)13(19)17(10-22-2)15(21)18(11-23-3)14(16)20/h5-9H,4,10-11H2,1-3H3
Eterobarb (Antilon) is a barbiturate derivative. It is an effective anticonvulsant as demonstrated
in animal and clinical studies. Eterobarb possesses a unique and clinically intriguing
feature-at therapeutically effective blood levels, the hypnotic side effects usually associated
with barbiturates appear absent. Though effective
against both electrically and chemically induced
seizures in mice and rats, virtually no hypnotic effects were
noted except at lethal doses. Double-blind
cross-over studies have confirmed the anticonvulsant
efficacy of eterobarb and
several phase II and phase Ill studies show eterobarb
to be an effective anticonvulsant with less
hypnotic activity when compared with phenobarbital.
Eterobarb had been NDA filed for the treatment of epilepsy in the US, UK, Switzerland and Canada. However, this research has been discontinued. The compound was originated by Colgate Palmolive, then licensed to MacroChem.
CNS Activity
Originator
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3956454
Group 1 received eterobarb in an initial dose of
360 mg/day.
Route of Administration:
Oral
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NCI_THESAURUS |
C67084
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C77629
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DTXSID9045710
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27511-99-5
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3193
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m5040
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432SI047GA
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C010451
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33925
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100000082393
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CHEMBL327407
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ETEROBARB
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ACTIVE MOIETY