Olivomycin is an antitumor glycoside antibiotic that binds to DNA. This drug is used to treat testicular neoplasms, tonsillar tumors and reticulosarcoma with peripheral nodes. In addition, olivomycin was studied for the diagnosis of ureaplasma infection of the sperm.

Streptovaricins (or streptovarycins) are a group of structurally related macrolide antibiotics, which are active against gram-positive and gram-negative bacteria and especially against Mycobacterium tuberculosis. It was shown, that streptovaricin probably blocked transcription of adenovirus 2 (AD2) by inhibiting early transcription complex assembly events.

Partricin, a heptaene macrolide antibiotic, has been separated into three polyene components, partricins A, B and C. Partricin was used as an antifungal and antiprotozoal agent. Information about the current use of this drug is not available.

Ramoplanin is a glycolipodepsipeptide antibiotic obtained from the fermentation of Actinoplanes sp. ATCC 33076 that exhibits activity against clinically important multi-drug-resistant, Gram-positive pathogens including vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-intermediate resistant Clostridium difficile. Ramoplanin was first isolated as a complex of three closely related components A1, A2, and A3. Preclinical studies have also demonstrated that ramoplanin exerts a rapid bactericidal effect on S. aureus biofilms and that a clinical vancomycin-resistant S. aureus strain containing the vanA gene was susceptible to ramoplanin. Ramoplanin blocks bacterial cell wall biosynthesis by interfering with peptidoglycan production. Ramoplanin inhibits the N-acetylglucosaminyltransferase-catalysed conversion of lipid intermediate I to lipid intermediate II, a step that occurs before the transglycosylation and transpeptidation reactions. Ramoplanin’s mechanism of action is distinct from that of glycopeptides. Unlike glycopeptides, ramoplanin does not complex with the D-Ala–D-Ala sequence of cell wall precursors. Ramoplanin is being developed for the targeted prophylaxis of recently treated patients with C. difficile infection (CDI) at high risk for infection relapse. Twelve Phase I studies, two Phase II studies (one in CDI and one in VRE) as well as one Phase III study (in VRE) have been conducted

Viridofulvin is an antibiotic derived from Streptomyces viridogriseus. This compound was studied as an antifungal. However, information about the current use of viridofulvin is not available.

The paulomycins are a group of glycosylated compounds isolated from several different Streptomyces strains. It was found that all paulomycins and their analogs possessed excellent antibiotic activity against Gram-positive bacteria, and some exhibited substantial activity against a range of other microorganisms for the treating urethritis and Chlamydia infections.

Paldimycin (also known as U-70138F) was developed as an antimicrobial drug, which was highly active against Gram-positive bacteria, e.g., against Staphylococcus aureus via inhibition of protein synthesis. In addition, paldimycin was highly active against C. trachomatis in cell culture. However, information about the further development of this drug is not available.