Streptovaricins (or streptovarycins) are a group of structurally related macrolide antibiotics, which are active against gram-positive and gram-negative bacteria and especially against Mycobacterium tuberculosis. It was shown, that streptovaricin probably blocked transcription of adenovirus 2 (AD2) by inhibiting early transcription complex assembly events.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues. | 2017-10-20 |
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| Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis. | 2010-05 |
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| [Effect of streptovaricin on the multiplication of L line cells]. | 1978 |
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| Streptovaricins inhibit focus formation by MSV (MLV) complex. | 1971-08 |
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| Inhibition of nucleoside incorporation into HeLa cells by streptovaricin. | 1971-01-22 |
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| [Streptovaricin, a new antibiotic; effects on Mycobacterium tuberculosis in vitro]. | 1958-05-01 |
Sample Use Guides
Streptovaricin inhibited the L cell multiplication, rendering no significant effect on that of normal fibroblasts of C3H mice culture. In a dose of 4 mkg/ml streptovaricin would induce an increase of the DNA amount in L cell nuclei, while its dosage of 8 mkg/ml decrease the amount of DNA, resulting in the differentiation of some population cells.
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