Streptovaricins (or streptovarycins) are a group of structurally related macrolide antibiotics, which are active against gram-positive and gram-negative bacteria and especially against Mycobacterium tuberculosis. It was shown, that streptovaricin probably blocked transcription of adenovirus 2 (AD2) by inhibiting early transcription complex assembly events.
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Streptovaricin inhibited the L cell multiplication, rendering no significant effect on that of normal fibroblasts of C3H mice culture. In a dose of 4 mkg/ml streptovaricin would induce an increase of the DNA amount in L cell nuclei, while its dosage of 8 mkg/ml decrease the amount of DNA, resulting in the differentiation of some population cells.
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C261
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