PALDIMYCIN

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3571055 | https://www.ncbi.nlm.nih.gov/pubmed/3467650

Paldimycin (also known as U-70138F) was developed as an antimicrobial drug, which was highly active against Gram-positive bacteria, e.g., against Staphylococcus aureus via inhibition of protein synthesis. In addition, paldimycin was highly active against C. trachomatis in cell culture. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.	1988-05	2840019
In-vitro activity of paldimycin against methicillin-resistant and susceptible isolates of Staphylococcus aureus and S. epidermidis.	1987-08	3667485
In vitro activity of paldimycin (U-70138F) against gram-positive bacteria isolated from patients with cancer.	1987-04	3606069
Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.	1986-11	3467650
Evaluation of antibacterial agents in a high-volume bovine polymorphonuclear neutrophil Staphylococcus aureus intracellular killing assay.	1986-04	2871811

Substance Class	Mixture Created by `admin` on `Mon Mar 31 19:21:30 GMT 2025` Edited by `admin` on `Mon Mar 31 19:21:30 GMT 2025`
Record UNII	H849Q7B10B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PALDIMYCIN

Official Name

English

U-70138

Preferred Name

English

ANTIBIOTIC PRODUCED BY STREPTOMYCES ORGANISM AS A MIXTURE OF PALDIMYCIN A AND PALDIMYCIN B IN APPROXIMATELY 1:1 RATIO

Common Name

English

ANTIBIOTIC 273A1

Common Name

English

PALDIMYCIN [USAN]

Common Name

English

paldimycin [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C170283