PALDIMYCIN

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3571055 | https://www.ncbi.nlm.nih.gov/pubmed/3467650

Paldimycin (also known as U-70138F) was developed as an antimicrobial drug, which was highly active against Gram-positive bacteria, e.g., against Staphylococcus aureus via inhibition of protein synthesis. In addition, paldimycin was highly active against C. trachomatis in cell culture. However, information about the further development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Evaluation of antibacterial agents in a high-volume bovine polymorphonuclear neutrophil Staphylococcus aureus intracellular killing assay.	1986 Apr	2871811
Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.	1986 Nov	3467650
In vitro activity of paldimycin (U-70138F) against gram-positive bacteria isolated from patients with cancer.	1987 Apr	3606069
In-vitro activity of paldimycin against methicillin-resistant and susceptible isolates of Staphylococcus aureus and S. epidermidis.	1987 Aug	3667485
In vitro activities of daptomycin (LY146032) and paldimycin (U-70,138F) against anaerobic gram-positive bacteria.	1988 May	2840019

Substance Class	Mixture Created by `admin` on `Fri Dec 15 18:48:22 GMT 2023` Edited by `admin` on `Fri Dec 15 18:48:22 GMT 2023`
Record UNII	H849Q7B10B
Record Status	`Validated (UNII)`
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Name

Type

Language

PALDIMYCIN

Official Name

English

ANTIBIOTIC PRODUCED BY STREPTOMYCES ORGANISM AS A MIXTURE OF PALDIMYCIN A AND PALDIMYCIN B IN APPROXIMATELY 1:1 RATIO

Common Name

English

ANTIBIOTIC 273A1

Common Name

English

PALDIMYCIN [USAN]

Common Name

English

paldimycin [INN]

Common Name

English

U-70138

Code

English

Code System Code Type Description

NCI_THESAURUS

C170283