STREPTOVARYCIN

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28858479

Streptovaricins (or streptovarycins) are a group of structurally related macrolide antibiotics, which are active against gram-positive and gram-negative bacteria and especially against Mycobacterium tuberculosis. It was shown, that streptovaricin probably blocked transcription of adenovirus 2 (AD2) by inhibiting early transcription complex assembly events.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
early transcription complex assembly 1 Target ID: early transcription complex assembly Sources: https://www.ncbi.nlm.nih.gov/pubmed/2905235	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13591616	Curative		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Streptovaricin, a new antibiotic; effects on Mycobacterium tuberculosis in vitro].	1958 May-Jun	13562631
Streptovaricins inhibit focus formation by MSV (MLV) complex.	1971 Aug	4398427
Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.	2010 May	20176899
Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues.	2017 Oct 20	28858479

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Streptovaricin inhibited the L cell multiplication, rendering no significant effect on that of normal fibroblasts of C3H mice culture. In a dose of 4 mkg/ml streptovaricin would induce an increase of the DNA amount in L cell nuclei, while its dosage of 8 mkg/ml decrease the amount of DNA, resulting in the differentiation of some population cells.

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STREPTOVARYCIN