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Restrict the search for
hydrocortisone butyrate
to a specific field?
Class (Stereo):
CHEMICAL (ABSOLUTE)
Mazokalim is a potassium channel agonist. It was studied in the treatment of asthma and hypertension.
Status:
Investigational
Source:
NCT04566679: Not Applicable Interventional Unknown status Irritable Bowel Syndrome (IBS)
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Resocortol is a synthetic corticosteroid. Information about current use of this compound is not available.
Class (Stereo):
CHEMICAL (MIXED)
Naboctate (SP-325) is a synthetic cannabinoid receptor agonist, which has antiemetic, sedative, anxiolytic and anti-glaucoma properties. In a normotensive rabbit model, topically applied naboctate in aqueous solution induced dose-related decreases in intraocular pressure.
Status:
Investigational
Source:
USAN:ROSARAMICIN BUTYRATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (ABSOLUTE)
Domoprednate is a corticosteroid, a glucocorticoid, with anti-inflammatory and anti-allergic properties. Domoprednate is inferior to betamethasone valerate in the same category of dermatoses and equally well tolerated. It can be characterized as a medium-active corticosteroid. Domoprednate can be used topically in the treatment of skin disorders, such as eczema, psoriasis and atopic dermatitis.
Status:
Investigational
Source:
NCT00002677: Phase 1 Interventional Completed Prostate Cancer
(1995)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Tributyrin is a prodrug of natural butyrate. It is a neutral short-chain fatty acid triglyceride that is likely to overcome the pharmacokinetic drawbacks of natural butyrate as a drug. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects in neoplastic cells. Compared with butyrate, tributyrin has more favorable pharmacokinetics and is well tolerated. Because it is rapidly absorbed and chemically stable in plasma, tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing therapeutically effective butyrate over time directly into the cell. Tributyrin may, at least in part, exert its growth-reducing and differentiation-inducing effect in Caco-2 cells by an upregulation of the vitamin D receptor; this may provide a useful therapeutic approach in chemoprevention and treatment of colorectal cancer. In phase I study of the orally administered tributyrin there was no consistent increase in hemoglobin F. Peak plasma butyrate concentrations occurred between 0.25 and 3 h after dose. Development of tributyrin as an anticancer agent was discontinued.
Class (Stereo):
CHEMICAL (MIXED)
Nabazenil is a synthetic cannabinoid receptor agonist, which has anticonvulsant properties. Nabazenil was undergoing preclinical trials with HG Pars in the USA.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
11-Deoxycortisol (also known as cortodoxone) is the predominant deoxycorticosteroid and is the immediate precursor of cortisol, which is formed by the enzymatic action of 11beta-hydrozylase (P450). Deficiency of this enzyme causes congenital adrenal hyperplasia, which is characterized by hypertension. 11-deoxycortisol is measured as part of the Metyrapone Test. Metyrapone blocks the formation of cortisol, resulting in increased secretion of Adrenocorticotropic hormone (ACTH) and 11-deoxycortisol in normal individuals.
