DOMOPREDNATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H36O5
Molecular Weight	428.561
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC(=O)O[C@@]1(CCC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(C)=O

InChI

InChIKey=IYBYNRHXGXDDDS-VRRJBYJJSA-N

InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H36O5
Molecular Weight	428.561
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3653463 | https://www.ncbi.nlm.nih.gov/pubmed/3888709 | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 104, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Domoprednate is a corticosteroid, a glucocorticoid, with anti-inflammatory and anti-allergic properties. Domoprednate is inferior to betamethasone valerate in the same category of dermatoses and equally well tolerated. It can be characterized as a medium-active corticosteroid. Domoprednate can be used topically in the treatment of skin disorders, such as eczema, psoriasis and atopic dermatitis.

Approval Year

PubMed

Title	Date	PubMed
Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate.	1987	3653463
Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo.	1985	3888708
The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial.	1985	3888709
A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses.	1984	6370748

Patents

Sample Use Guides

In Vivo Use Guide

The 0.1% ointment was applied twice daily for 4 weeks.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:14 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:14 GMT 2025`
Record UNII	910G0QIM2M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DOMOPREDNATE

Official Name

English

RO 12-7024

Preferred Name

English

11.BETA.,17A-DIHYDROXY-D-HOMOPREGNA-1,4-DIENE-3,20-DIONE 17A-BUTYRATE

Common Name

English

domoprednate [INN]

Common Name

English

DOMOPREDNATE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521