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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H36O5
Molecular Weight 428.561
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DOMOPREDNATE

SMILES

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CCC[C@]4(OC(=O)CCC)C(C)=O

InChI

InChIKey=IYBYNRHXGXDDDS-VRRJBYJJSA-N
InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1

HIDE SMILES / InChI

Molecular Formula C26H36O5
Molecular Weight 428.561
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

Domoprednate is a corticosteroid, a glucocorticoid, with anti-inflammatory and anti-allergic properties. Domoprednate is inferior to betamethasone valerate in the same category of dermatoses and equally well tolerated. It can be characterized as a medium-active corticosteroid. Domoprednate can be used topically in the treatment of skin disorders, such as eczema, psoriasis and atopic dermatitis.

Approval Year

PubMed

PubMed

TitleDatePubMed
A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses.
1984
Patents

Patents

Sample Use Guides

The 0.1% ointment was applied twice daily for 4 weeks.
Route of Administration: Topical
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:04:27 GMT 2023
Edited
by admin
on Fri Dec 15 16:04:27 GMT 2023
Record UNII
910G0QIM2M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DOMOPREDNATE
INN   MART.  
INN  
Official Name English
11.BETA.,17A-DIHYDROXY-D-HOMOPREGNA-1,4-DIENE-3,20-DIONE 17A-BUTYRATE
Common Name English
domoprednate [INN]
Common Name English
RO 12-7024
Code English
DOMOPREDNATE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C521
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
Code System Code Type Description
PUBCHEM
68868
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
ECHA (EC/EINECS)
266-506-0
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
FDA UNII
910G0QIM2M
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
SMS_ID
100000080760
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
CAS
66877-67-6
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
NCI_THESAURUS
C65464
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
WIKIPEDIA
Domoprednate
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
EVMPD
SUB06359MIG
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID801024405
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
MESH
C045340
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
INN
5137
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106538
Created by admin on Fri Dec 15 16:04:27 GMT 2023 , Edited by admin on Fri Dec 15 16:04:27 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY