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Restrict the search for
m landiolol
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Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Dimethyl phthalate, an organic compound, is used as repellents. This compound is a pollutant that is very harmful to organisms due to its mutagenicity, teratogenicity and carcinogenicity. It was discovered, that dimethyl phthalate could alter the biological function of the one of the most important bacteria in the environment, P. fluorescens.
Status:
Possibly Marketed Outside US
Source:
Stakane by Dausse [France]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Antrafenine (SL 73033 or 2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl 2-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoate) showed marked analgesic activity, long duration of action, and excellent tolerance in pharmacological and toxicological studies. Antrafenine exerts anti-inflammatory effects. It has been studied in the treatment of osteoarthritis.
Status:
Possibly Marketed Outside US
Source:
TANADOPA by Tanabe Seiyaku
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Docarpamine (marketed under the tradename Tanadopa) is a dopamine prodrug developed in Japan for the treatment of chronic heart failure. The drug does not cross the blood-brain barrier and shows no effect on CNS activity. It is supposed that the drug exerts its action by activating dopamine receptor D1.
Status:
Possibly Marketed Outside US
Source:
Broperamole by Onbio Inc.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Broperamole has been studied as an anti-inflammatory agent.
Status:
Possibly Marketed Outside US
Source:
Unknown by ICN Pharmaceuticals
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Tiazofurin (NSC-286193; 2-beta-D-ribofuranosylthiazole-4-carboxamide) an approved chronic myeloid leukemia (CML) drug, is converted by cellular enzymes into tiazofurin adenine dinucleotide, TAD, which inhibits the enzyme as a cofactor mimic. Resistance to tiazofurin is quickly developed due to diminished ability of resistant cells to synthesize TAD and increased enzymatic degradation of TAD. It is a nucleoside analog with oncolytic activity being developed by Ribapharm (formerly ICN Pharmaceuticals) as a potential treatment for leukemia. Ribapharm, through a Russian subsidiary of ICN, is planned to conduct phase II studies of tiazofurine involving patients suffering from advanced ovarian cancer or multiple myeloma which is resistant to conventional therapy.
Status:
Possibly Marketed Outside US
Source:
NCT00180102: Phase 4 Interventional Completed Leukemia, Nonlymphocytic, Acute
(2003)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. Although its mechanism of action is incompletely defined, amsacrine inhibits DNA synthesis by binding to and intercalating with DNA. Amsacrine also inhibits topoisomerase II activity and may exert an effect on cell membranes. This agent also possesses immunosuppressive and antiviral properties. While amsacrine is not cell cycle phase-specific, cytotoxicity is maximal during the G2 and S phases.
Status:
Possibly Marketed Outside US
Source:
Lamuran by Janot, M.-M.|Le Men, J.|Djerassi, C.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
The Rauwolfia alkaloid, raubasine (ajmalicine), has been found to have broad application in the treatment of circulatory diseases, especially in the relief of obstruction of normal cerebral blood flow. In combination with other Rauwolfia alkaloids it has been used to lower high blood pressure. Raubasine is an antihypertensive drug used in the treatment of high blood pressure. It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, and Sarpan. Raubasine acts as a α1-adrenergic receptor antagonist.
Status:
Possibly Marketed Outside US
Source:
Amflutizole by Onbio Inc.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
AMFLUTIZOLE is a xanthine oxidase inhibitor used for the treatment of gout.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (RACEMIC)
Nilvadipine (NIVADIL®) is a L-type calcium channel blocker for treatment of hypertension. It inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (EPIMERIC)
Conditions:
Tolciclate [O-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl)-m,N-dimethylthiocarbanilate] is an antimycotic agent with specific activity on dermatophytes. In vitro it is as active as tolnaftate, but shows greater liposolubility, which might be important for in vivo activity. When applied topically for 10 days to guinea pigs infected acutely with Trichophyton mentagrophytes (synonymous with T. asteroides), it is about three times more active than tolnaftate. Inhibition by tolciclate of sterol synthesis through blocking the step of squalene epoxidation in a fungal sterol biosynthetic pathway may be primarily involved in the antifungal action of the drug.
