Details
Stereochemistry | ACHIRAL |
Molecular Formula | C30H26F6N4O2 |
Molecular Weight | 588.5435 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC2=C(C=C1)C(NC3=C(C=CC=C3)C(=O)OCCN4CCN(CC4)C5=CC(=CC=C5)C(F)(F)F)=CC=N2
InChI
InChIKey=NWGGKKGAFZIVBJ-UHFFFAOYSA-N
InChI=1S/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38)
Antrafenine (SL 73033 or 2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl 2-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoate) showed marked analgesic activity, long duration of action, and excellent tolerance in pharmacological and toxicological studies. Antrafenine exerts anti-inflammatory effects. It has been studied in the treatment of osteoarthritis.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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[Ionized fluorine in the plasma and urine of subjects treated with organofluorine drugs prescribed in rheumatology]. | 1979 Feb |
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Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. | 1979 May |
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A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. | 1983 |
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Antrafenine, naproxen and placebo in osteoarthritis: a comparative study. | 1983 May |
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Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat. | 1984 Feb |
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In-vivo metabolism in the rat and mouse of antrafenine to 1-m-trifluoromethylphenylpiperazine. | 1985 Jan |
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[Identification of a metabolite of floctafenine in urinary calculi]. | 1987 |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C245
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3939
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DTXSID60203833
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68723
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CHEMBL345524
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C017014
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m52
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ANTRAFENINE
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55300-29-3
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3677
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DB01419
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C72107
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SUB05530MIG
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100000086973
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21FS93Y6OE
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ACTIVE MOIETY