U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2471 - 2480 of 2551 results

Status:
US Previously Marketed
Source:
piperocaine
(1933)
Source URL:
First marketed in 1933
Source:
piperocaine
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)



Piperocaine (Metycaine) is a local anesthetic drug. It is an ester and primarily is a sodium channel blocker. Piperocaine can partially inhibit dopamine. It is known as a alpha-1-proteinase inhibitor. Used in the form of its hydrochloride as a local or spinal anesthetic and in dental anesthesia. Can cause toxic reactions. Piperocaine Hydrochloride is in the list of Bulk Drug Substances Nominated for Use in Compounding Under Section 503A, FDA Act. Piperocaine hydrochloride is a small, white odorless crystals or a white crystalline powder, stable in air, freely soluble in water, alcohol and chloroform.
Status:
US Previously Marketed
Source:
Aconitine U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Aconitine U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Aconitine is an alkaloid found in the Aconitum species. Aconitine is a highly toxic cardiotoxin and neurotoxin. In China and other countries, the herbal extract containing aconitine was used for the treatment of pain in musculoskeletal disorders, however the safety margin between therapeutic analgesic effect of aconitine and its known cardiotoxic effect is so narrow that the treatment may cause poisoning and death. The mechanism of aconitine action is explained by its ability to activate voltage-dependent sodium-ion channels.
Status:
US Previously Marketed
Source:
Aconitine U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Aconitine U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Aconitine is an alkaloid found in the Aconitum species. Aconitine is a highly toxic cardiotoxin and neurotoxin. In China and other countries, the herbal extract containing aconitine was used for the treatment of pain in musculoskeletal disorders, however the safety margin between therapeutic analgesic effect of aconitine and its known cardiotoxic effect is so narrow that the treatment may cause poisoning and death. The mechanism of aconitine action is explained by its ability to activate voltage-dependent sodium-ion channels.
Amylocaine (trade name Stovaine) is a local anesthetic, that was widely used for spinal anesthesia in Caesarean section. The dose used would produce anesthesia for up to 1 h. Reports of the use of spinal analgesia for abdominal and perineal surgery in infants are found from several centers during the first half of the twentieth century. However, this agent often fails to provide good maternal sensory block and currently, Amylocaine has been replaced with new anesthetics.
Status:
US Previously Marketed
Source:
beta-Eucaine by E. Schering, Berlin, Germany (Scherlng & Giatz, New York).
(1897)
Source URL:
First marketed in 1897

Class (Stereo):
CHEMICAL (RACEMIC)


Class (Stereo):
CHEMICAL (ACHIRAL)

LAURALKONIUM is an antiseptic.

Showing 2471 - 2480 of 2551 results