11-Deoxycortisol (also known as cortodoxone) is the predominant deoxycorticosteroid and is the immediate precursor of cortisol, which is formed by the enzymatic action of 11beta-hydrozylase (P450). Deficiency of this enzyme causes congenital adrenal hyperplasia, which is characterized by hypertension. 11-deoxycortisol is measured as part of the Metyrapone Test. Metyrapone blocks the formation of cortisol, resulting in increased secretion of Adrenocorticotropic hormone (ACTH) and 11-deoxycortisol in normal individuals.

Naflocort (SQ 26,490) is a topical anti-inflammatory adrenocortical steroid. It was a moderately potent inhibitor of edema formation in the rat. After extended topical application, SQ 26,490 totally inhibited edema formation without appreciable production of skin atrophy, measured under identical conditions. SQ 26,490 possesses the property for a greater separation of anti-inflammatory and atrophogenic activities than comparative corticoids.

aloprogesterone, a progestin agent, was marketed under the brand name Prohalone, but now is not available.

Fluasterone is a fluorinated derivative of an endogenous steroid hormone androstenolone (dehydroepiandrosterone, DHEA). According to in vivo studies, fluasterone possess endocrinologic effects manifested in increased estrous cycle length and decreased the weights of the uterus, prostate, seminal vesicles, and testes. The mechanism of action of fluasterone is not yet fully elucidated, but most likely involve inhibition of glucose-6-phosphate hydrogenase. Fluasterone was developed by Aeson Therapeutics and was investigated in the late 1990s for the treatment of asthma, cancer, cardiovascular and metabolic disorders. The development of fluasterone for discontinued, probably due to a combination of low potency and insufficient oral bioavailability. Later, the development of fluasterone was continued by the company SteroTherapeutics. In 2018 the FDA has granted an orphan drug designation for fluasterone for the treatment of nonalcoholic fatty liver disease, nonalcoholic steatosis, and hyperglycemia in patients with Cushing’s syndrome.

17-epidrospirenone is an epimer of drospirenone, considered to be impurity. Drospirenone is a synthetic progestational compound used as a component of oral contraceptive in combination with ethinyl estradiol.

16alpha-hydroxyestrone is a naturally occurring estrone metabolite. It exerts estrogenic properties through covalent estrogen receptor (ER) binding. 16alpha-hydroxyestrone is a potential tumor initiator. The ratio 2-hydroxyestrone to 16alpha-hydroxyestrone could serve as an innovative intermediate biomarker for breast cancer risk. This biomarker could be used to identify women at high risk, and provide the analytic framework for the development of new pharmaceutical and dietary intervention strategies.

6α-fluorotestosterone (6α-fluoro T) acts as a competitive inhibitor of aromatase cytochrome P450. The mechanism by which substitution of a fluorine at the 6 alpha-position interferes with the aromatization reaction remains to be determined, but the inhibitory action on estrogen formation may potentiate the androgenic properties of 6 alpha-fluorotestosterone in vivo due to a lowering of estrogen levels. Besides, 6α-fluoroT promotes male sex behavior, it does not promote mating by unassisted estrogen receptor binding and it does not promote mating via metabolism to another androgen.

Nandrolone hexyloxyphenylpropionate (brand names Anador, Anadur, Anadurine) is a synthetic androgen and anabolic steroid is marketed in some countries. Nandrolone, in general, is more anabolic than testosterone and has a very low androgenic expression. It is reported to have an anabolic to androgenic ratio of 37:125. Typically, males would take a dosage range of 200-600mg/wk with higher doses sometimes found in more advanced users. This compound normally would not be recommended for women due to the virilization effects this compound may cause such as increased body hair, deepened voice. Anadur has a high affinity towards the androgen receptor while having a lower androgenic expression, it is usually not recommended to be taken without testosterone. Without a high androgenic expression and having a strong bond to the AR, side effects of low testosterone are possible such as the infamous "Deca-Dick" (impotence), lethargy, and low sex drive.