19-NORPROGESTERONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H28O2
Molecular Weight	300.4351
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]23[H]

InChI

InChIKey=NVUUMOOKVFONOM-GPBSYSOESA-N

InChI=1S/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H28O2
Molecular Weight	300.4351
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Experimental hypertension induced by 19-nor-progesterone treatment in the rat.	1981 Oct	7285864
Ovarian function during use of vaginal rings delivering three different doses of Nestorone.	2001 May	11448466
Classification and pharmacology of progestins.	2003 Dec 10	14670641
[Effects of a 19-norprogesterone derivative, the fourth decade nomegestrol acetate, on lipids].	2003 Jun	12910065
Development of the selective progesterone receptor modulator CDB-2914 for clinical indications.	2003 Nov	14667994
Nestorone: clinical applications for contraception and HRT.	2003 Nov	14667982
New progestogens: a review of their effects in perimenopausal and postmenopausal women.	2004	15493951
Pharmacological profile of progestins.	2004 Apr 15	15063480
Clinical profile of contraceptive progestins.	2004 Sep	15697108
[Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate].	2005 Feb	15767920
Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease.	2006 Mar 13	16533397
New progestagens for contraceptive use.	2006 Mar-Apr	16291771
Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function.	2006 Nov 3	17083736
Routes of delivery for progesterone and progestins.	2007 May 20	17368973
Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay.	2008 May	18395441
Evaluation of extended and continuous use oral contraceptives.	2008 Oct	19209272
Pharmacological profile of progestins.	2008 Sep-Oct	19434887
Different cardiovascular effects of progestins according to structure and activity.	2009	19811251
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.	2009 Dec 31	20087430
The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2.	2009 Jun	19811365
[Nomegestrol acetate: clinical pharmacology].	2009 Oct	19749678
Emergency contraception: potential role of ulipristal acetate.	2010 Aug 9	21072297
Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy.	2010 Mar 26	20329803

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:32:53 GMT 2023` Edited by `admin` on `Sat Dec 16 05:32:53 GMT 2023`
Record UNII	1A5185976G
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

19-NORPROGESTERONE

Common Name

English

NSC-22021

Code

English

19-NORPREGN-4-ENE-3,20-DIONE

Common Name

English

NORPROGESTERONE

Common Name

English

U-25879

Code

English

19-NOR-P4

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C776