Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.4351 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]23[H]
InChI
InChIKey=NVUUMOOKVFONOM-GPBSYSOESA-N
InChI=1S/C20H28O2/c1-12(21)18-7-8-19-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h11,15-19H,3-10H2,1-2H3/t15-,16+,17+,18+,19-,20+/m0/s1
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.4351 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Experimental hypertension induced by 19-nor-progesterone treatment in the rat. | 1981 Oct |
|
| Withdrawal of hormone replacement therapy is associated with significant vertebral bone loss in postmenopausal women. | 2001 |
|
| Ovarian function during use of vaginal rings delivering three different doses of Nestorone. | 2001 May |
|
| Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. | 2002 Jan |
|
| [Pharma-Clinics. Medication of the month. Totelle Cycle: new sequential estrogen/progesterone regimen for hormone replacement therapy in menopause]. | 2002 Jun |
|
| Classification and pharmacology of progestins. | 2003 Dec 10 |
|
| [Antigonadotropic effects of a 19-nor-progesterone derivative: the example of nomegestrol acetate]. | 2003 Jan |
|
| [Effects of a 19-norprogesterone derivative, the fourth decade nomegestrol acetate, on lipids]. | 2003 Jun |
|
| Development of the selective progesterone receptor modulator CDB-2914 for clinical indications. | 2003 Nov |
|
| Nestorone: clinical applications for contraception and HRT. | 2003 Nov |
|
| New progestogens: a review of their effects in perimenopausal and postmenopausal women. | 2004 |
|
| Pharmacological profile of progestins. | 2004 Apr 15 |
|
| Clinical profile of contraceptive progestins. | 2004 Sep |
|
| [Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate]. | 2005 Feb |
|
| Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease. | 2006 Mar 13 |
|
| New progestagens for contraceptive use. | 2006 Mar-Apr |
|
| Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. | 2006 Nov 3 |
|
| Routes of delivery for progesterone and progestins. | 2007 May 20 |
|
| Structure-activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay. | 2008 May |
|
| Evaluation of extended and continuous use oral contraceptives. | 2008 Oct |
|
| Classification and pharmacology of progestins. | 2008 Sep-Oct |
|
| Pharmacological profile of progestins. | 2008 Sep-Oct |
|
| Different cardiovascular effects of progestins according to structure and activity. | 2009 |
|
| Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. | 2009 Dec 31 |
|
| The hypertensiogenetic steroid 19-nor-progesterone does not influence cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2. | 2009 Jun |
|
| [Nomegestrol acetate: clinical pharmacology]. | 2009 Oct |
|
| Emergency contraception: potential role of ulipristal acetate. | 2010 Aug 9 |
|
| Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy. | 2010 Mar 26 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:32:53 GMT 2023
by
admin
on
Sat Dec 16 05:32:53 GMT 2023
|
| Record UNII |
1A5185976G
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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Download
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Code | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C776
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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472-54-8
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY | |||
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19-NORPROGESTERONE
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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DTXSID40197064
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY | |||
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22021
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY | |||
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228864
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY | |||
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C29782
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY | NCIT | ||
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1A5185976G
Created by
admin on Sat Dec 16 05:32:53 GMT 2023 , Edited by admin on Sat Dec 16 05:32:53 GMT 2023
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PRIMARY |