Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H22O3 |
Molecular Weight | 286.3655 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H](O)C(=O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4
InChI
InChIKey=WPOCIZJTELRQMF-QFXBJFAPSA-N
InChI=1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,18+/m1/s1
Molecular Formula | C18H22O3 |
Molecular Weight | 286.3655 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
16alpha-hydroxyestrone is a naturally occurring estrone metabolite. It exerts estrogenic properties through covalent estrogen receptor (ER) binding. 16alpha-hydroxyestrone is a potential tumor initiator. The ratio 2-hydroxyestrone to 16alpha-hydroxyestrone could serve as an innovative intermediate biomarker for breast cancer risk. This biomarker could be used to identify women at high risk, and provide the analytic framework for the development of new pharmaceutical and dietary intervention strategies.
Approval Year
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16122183
The ovarian cancer cell line OVCAR-3 were incubated with 16alpha-hydroxyestrone (16-OHE1) for seven days in the concentration range of 0.01 nM to 10 nM. 16-OHE1 treatment exerts the proliferative and antiapoptotic effect.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:20:09 GMT 2023
by
admin
on
Sat Dec 16 08:20:09 GMT 2023
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Record UNII |
JY611949JU
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C2181
Created by
admin on Sat Dec 16 08:20:09 GMT 2023 , Edited by admin on Sat Dec 16 08:20:09 GMT 2023
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Code System | Code | Type | Description | ||
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16α-Hydroxyestrone
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JY611949JU
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115116
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DTXSID901047947
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566-76-7
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776
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C120468
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admin on Sat Dec 16 08:20:09 GMT 2023 , Edited by admin on Sat Dec 16 08:20:09 GMT 2023
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PRIMARY | NCIT | ||
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SUB14145MIG
Created by
admin on Sat Dec 16 08:20:09 GMT 2023 , Edited by admin on Sat Dec 16 08:20:09 GMT 2023
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Related Record | Type | Details | ||
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PARENT -> METABOLITE |
IN-VIVO
URINE
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PARENT -> METABOLITE |
IN-VIVO
URINE
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