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Restrict the search for
dopamine
to a specific field?
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Amfonelic acid (AFA) is a dopamine reuptake inhibitor. Experiments on rats have shown that AFA treatment completely prevented the effects of methamphetamine on the dopaminergic system, both morphologically and biochemically.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Tiomergine is an ergot alkaloid derivative. It is the agonist of the postulated presynaptic dopamine receptor. Tiomergine is the antiparkinsonian agent. Tiomergine modified brain glucose metabolism in a way similar to the neuroleptics but different from postsynaptic agonists. It was ineffective in the treatment of tardive dyskinesia.
Status:
Investigational
Class (Stereo):
CHEMICAL (UNKNOWN)
Conditions:
Flazalone is a nonsteroidal anti-inflammatory drug. In acute irritant anti-inflammatory tests, flazalone exhibited a wide spectrum of activity. The compound was active in affecting the course of paw swelling in adjuvant arthritis when given daily either at the outset of the polyarthritis or after induction. The most unusual aspect of this compound is its ability to inhibit graft rejection in goldfish and rabbits.
Status:
Investigational
Source:
INN:milipertine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Milipertine was studied in patients with severe schizophrenia. Information about the current use of the drug is not available.
Status:
Investigational
Source:
Acta Psychiatr Scand. Jul 1977;56(1):57-61.: Not Applicable Human clinical trial Completed Dyskinesia, Drug-Induced
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Fusaric acid (J-butylpicolinic acid) is a fungal toxin with low to moderate toxicity synthesized by some Fusurium species which cause infections in cereal grains and other agricultural commodities. It may potentiate the effects of other Fusurium toxins. Fusaric acid is a potent inhibitor of DNA synthesis. Fusaric acid has potent anti-proliferative activity in vitro on various normal and cancer cell lines and suggest that it exhibits some cytotoxic specificity for growing and confluent colorectal adenocarcinoma and mammary adenocarcinoma cell lines. Fusaric acid is known as a potent dopamine-beta-hydroxylase inhibitor of high specificity. Fusaric acid calcium salt elicited the hypotensive response primarily through the reduction of total peripheral vascular resistance index.
Status:
Investigational
Source:
USAN:CLOTHIXAMIDE MALEATE [USAN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Protocatechuic acid (3,4-dihydroxybenzoic acid, PCA) is a simple phenolic acid. It is found in a large variety of edible plants and possesses various pharmacological activities. This bioactive compound is famous for its biological properties and pharmacological activities such as: antioxidant, antibacterial, anticancer, antiulcer, antidiabetic, antiaging, antifibrotic, antiviral, anti-inflammatory, analgesic, antiatherosclerotic, cardiac, hepatoprotective,
neurological and nephroprotective. The neuroprotective effects of PCA, extracted from Alpinia oxyphylla, on H2O2 resulted in apoptosis and oxidative stress in cultured PC12 cells. Apoptotic cell death by H2O2 was dose-dependent. Enhanced effect of PCA on protecting PC12 cells
against apoptosis, augmented glutathione (GSH)
level and an increase in catalytic activity was investigated
by flow cytometric analysis. In cytotoxic assays, PCA causes cell death in
HepG2 cancerous cell line of liver showing that
PCA stimulates the c-Jun N-terminal kinase (JNK)
and p38 subgroups of the mitogen-activated protein
kinase (MAPK) family. Treatment with
PCA decreased OVA-induced airway hyper-responsiveness
to inhaled methacholine. Cell inflammation
and mucus hypersecretion was also decreased by
PCA. Thus, PCA can be useful for treating asthma. Experimental studies strongly support the role of protocatechuic acid in the prevention of neurodegenerative processes, including Alzheimer's and Parkinson's diseases, due to its favorable influence on processes underlying cognitive and behavioral impairment, namely accumulation of the β-amyloid plaques in brain tissues, hyperphosphorylation of tau protein in neurons, excessive formation of reactive oxygen species and neuroinflammation.
![Structure of N-[(3R)-4-[4-(3-Chloro-5-ethyl-2-methoxyphenyl)-1-piperazinyl]-3-hydroxybutyl]-1H-indole-2-carboxamide](/img/a8de21d6-b5cb-4653-ba80-d1aa4bc6e467.svg?size=200&context=cqtxkmrcqy)
