TIOMERGINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H21N3S
Molecular Weight	347.477
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=CNC4=C3C(=CC=C4)C1=C[C@@H](CSC5=CC=CC=N5)CN2C

InChI

InChIKey=VCRAKEDGLIINLR-AUUYWEPGSA-N

InChI=1S/C21H21N3S/c1-24-12-14(13-25-20-7-2-3-8-22-20)9-17-16-5-4-6-18-21(16)15(11-23-18)10-19(17)24/h2-9,11,14,19,23H,10,12-13H2,1H3/t14-,19-/m1/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6149502 | https://www.ncbi.nlm.nih.gov/pubmed/6102461 | https://apps.who.int/iris/bitstream/handle/10665/68742/WHO_EDM_QSM_2004.5.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1206, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Tiomergine is an ergot alkaloid derivative. It is the agonist of the postulated presynaptic dopamine receptor. Tiomergine is the antiparkinsonian agent. Tiomergine modified brain glucose metabolism in a way similar to the neuroleptics but different from postsynaptic agonists. It was ineffective in the treatment of tardive dyskinesia.

Approval Year

PubMed

Title	Date	PubMed
Treatment of dyskinetic and dystonic disorders with CF 25-397: clinical and pharmacological aspects.	1980	6446848
Bromocriptine and CF 25-397 in the treatment of tardive dyskinesia.	1980 Apr	6102461
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics.	1984 Sep 7	6149502

Patents

Name

Type

Language

TIOMERGINE

Official Name

English

tiomergine [INN]

Common Name

English

9,10-DIDEHYDRO-6-METHYL-8B-((2-PYRIDYLTHIO)METHYL)ERGOLINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884