U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 191 - 200 of 2002 results

Status:
Investigational
Source:
INN:valdipromide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Valdipromide is an antidepressant.
Status:
Investigational
Source:
INN:clorindanic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Clorindanic acid is a choleretic indanol derivative. Sterling Drug Inc. patented the compound in the 1960s. The compound is claimed to cause an increase in the rate of bile flow when administered to dogs. In rats, clorindanic acid was shown to have mild analgesic activity and hyperthermic effect.
Status:
Investigational
Source:
INN:clofenamic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Clofenamic acid is a derivative of anthranilic acid, discovered by Parke-Davis. It possesses anti-inflammatory activity in the carrageenan-induced rat foot edema test.
Status:
Investigational
Source:
INN:clinolamide [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Clinolamide (cyclohexylamine of linoleic acid) is a drug developed by a Japanese company Sumitomo Chemical Co. Ltd. Clinolamide has been found to lower serum and liver cholesterol levels and to reduce the severity of atherosclerosis in cholesterol-fed rabbits.
Status:
Investigational
Source:
INN:tizoprolic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Tizoprolic acid is an anti-lipolytic drug, a blood ketone lowering agent.
Status:
Investigational
Source:
INN:nixylic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nixylic acid, an anilinonicotinic acid derivative, is an anti-inflammatory agent.
Status:
Investigational
Source:
INN:xanoxic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Xanoxic acid was developed as a bronchodilator that has never been marketed. Information about the current use of this agent is not available.
Status:
Investigational
Source:
INN:vestipitant [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Vestipitant, also known as GW597599, is a neurokinin1 receptor antagonist that was being developed by GlaxoSmithKline for the treatment of postoperative nausea and vomiting. Vestipitant is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) receptor blockade in the alleviation of anxiety and, possibly, depression. It was under development as a potential antiemetic and anxiolytic drug, and as a treatment for tinnitus and insomnia. Vestipitant was shown to improve sleep maintenance in patients with primary insomnia, with no associated next-day cognitive impairment. The effects on wake after sleep onset and total sleep time were maintained following repeated dosing. Vestipitant has anxiolytic properties and a good safety profile. Vestipitant was investigated for potential effect against chronic tinnitus as a stand-alone treatment and in conjunction with a selective serotonin reuptake inhibitor, paroxetine. Although well-tolerated vestipitant, alone or in combination with paroxetine, was not effective in ameliorating tinnitus in this patient group.
Status:
Investigational
Source:
INN:iotranic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iotranic Acid is triiodobenzoic acid derivative with potential application as new cholangiographic contrast media for liver imaging
Status:
Investigational
Source:
INN:ioxotrizoic acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Ioxotrizoic acid is acylated 3,5-diaminopolyhalobenzoic acid derivative patented by Sterling Drug Inc. as X-ray contrast agent for liver and spleen.