U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Showing 11 - 20 of 2,237 results

Status:
US Approved Rx (2014)
First approved in 1999

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:


NEO 212 is novel DNA alkylating agent exhibiting superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. NEO212 is a conjugate of temozolomide (TMZ,) with the natural product perillyl alcohol (POH...
Status:
US Approved Rx (2016)
First approved in 1996

Class (Stereo):
CHEMICAL (ACHIRAL)



Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors)....
Status:
US Approved Rx (2015)
First approved in 1996

Class (Stereo):
CHEMICAL (ABSOLUTE)



Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma gluco...
Status:
US Approved Rx (2015)
First approved in 1995

Class (Stereo):
CHEMICAL (RACEMIC)



Bicalutamide (brand name Casodex) is an oral non-steroidal anti-androgen for prostate cancer. It is indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma...
Status:
US Approved Rx (2010)
First approved in 1995

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Anastrozole (marketed under the trade name Arimidex by AstraZeneca) is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It decre...
Status:
US Approved Rx (2011)
First approved in 1995

Class (Stereo):
CHEMICAL (RACEMIC)



Tramadol (sold under the brand name Ultram) is a narcotic analgesic proposed for moderate to severe pain. Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors an...
Status:
US Approved Rx (2018)
First approved in 1994

Class (Stereo):
CHEMICAL (ACHIRAL)


Iobenguane I-131 is a radioactive therapeutic agent. The drug contains radioactive isotope I-131, which decays by electron emission with a half-life of about 8 days. By the chemical structure, iobenguane is similar to the neurotransmitter norepinephr...
Status:
US Approved Rx (1993)
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)



Lodoxamide is a mast-cell stabilizer for topical administration into the eye. This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. Lodoxamide inhibits the in vivo Type I immediate hypersensitivity reacti...
Status:
US Approved Rx (2005)
First approved in 1993

Class (Stereo):
CHEMICAL (ACHIRAL)



Torasemide is a pyridine-sulfonylurea type loop diuretic mainly used for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other ant...
Status:
US Approved Rx (2001)
First approved in 1989

Class (Stereo):
CHEMICAL (ACHIRAL)



Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or...

Showing 11 - 20 of 2,237 results