Emiglitate (BAYo1248/ BAY- O-1248) a deoxynojirimycin derivative, is an alpha-glucosidase inhibitor that is a powerful inhibitor of glucose-induced insulin release. It was investigated the effect of prolonged administration of this drug on blood glucose control, insulin requirements and breath hydrogen excretion in patients with insulin-dependent diabetes mellitus. And was obtained, that drug reduced postprandial hyperglycaemia and insulin requirements

Etilefrine is a cardiac stimulant used as an antihypotensive. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors. However, in vitro studies indicate that etilefrine has a much higher affinity for β1 (cardiac) than for β2 adrenoreceptors. Intravenous etilefrine increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Marked falls in pulse rate, cardiac output, stroke volume and peripheral bloodflow, accompanied by rises in mean arterial pressure, occur when etilefrine is infused after administration of intravenous propranolol 2,5 mg. These findings indicate that etilefrine has both β1 and α1 adrenergic effects in man. The French Health Products Agency concluded that etilefrine and heptaminol have an unfavourable harm-benefit balance, and also placed restrictions on the use of midodrine.

Lopinavir D-Valine Diastereomer, a selective HIV protease inhibitor, possesses similar properties with lopinavir.

Estriol acetate benzoate is a semisynthetic, steroidal estrogen. Estriol benzoate diacetate is reported as an ingredient of Holin in Japan. It is an estrogen receptor agonist.

Xanthine derivative, diisobutylaminobenzoyloxypropyl theophylline (Vestphyllin), is a vasodilator, bronchodilator.

Lappaconitine is an alkaloid isolated from the root of Aconltitum sinomantanum Nakai. It has a strong analgesic activity that does not involve the opioid receptor. It was shown to have class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor.

Silver benzoate is a water soluble crystalline salt composed of silver and benzoic acid with the formula C7H5AgO2 with marked antimicrobial activity. Silver benzoate can be used in synthesis of silver nanoparticle, and in the synthesis of triphenyltinbenzoate. Silver benzoate along with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD) is an efficient catalytic system for the reaction of carbon dioxide with various ketones.

Amidoflumet is a trifluoromethanesulfonanilide compound with high house dust miticidal activity which was discovered by Sumitomo Chemical, and was registered in Japan in 2004. House dust mites and their products are known to be major household allergens to children and the elderly, and they cause asthma and atopic dermatitis. Amidoflumet shows high lethal activity against common house dust mites.

Dimetofrine is a selective agonist of post-synaptic a1-adrenergic receptors. The drug was investigated as a cardiostimulant to treat orthostatic hypotension. Clinical investigation showed that dimetofrine relieves asthenia, paleness, drowsiness, fatigue, headache and other symptoms associated with hypotension. It was observed, that in acidic conditions similar to conditions in the stomach, dimetofrine is able to react with nitrites with the formation of highly mutagenic compound 2,6-dimethoxy-1,4-benzoquinone (DMBQ).

Tribenoside, a glucofuranoside derivative has been shown to have potent anti-allergic and anti-inflammatory properties. It has been reported to display a pluripotent antagonistic action against histamine, serotonin, bradykinin and other inflammatory substances. Tribenoside decrease capillary permeability, thus reducing edema. Tribenoside combat the pathological processes of capillaries and veins. It is used in adults and adolescents for treatment of venous circulation diseases. Although Tribenoside is derived from a sugar substance, it doesn’t affect the carbohydrate metabolism even in diabetics. Tribenoside might cause some side effects such as skin redness, headache. Very rare cases are: systemic anaphylaxis, including urticaria, angioedema.