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Restrict the search for
vitamin a palmitate
to a specific field?
Status:
Investigational
Source:
INN:limiglidole [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Limiglidole belongs to the class of benzimidazole derivatives exhibiting various biological activities including inhibition of platelet aggregation and prolongation of clotting time in animal models. It inhibited platelet aggregation induced by ADP. Antithrombotic activity of hypoglycemic compound limiglidole that exhibits antiplatelet activity 2-fold exceeded activity of antiplatelet agent acetylsalicylic acid in the mouse model of systemic collagen-epinephrine thrombosis. Antithrombogenic properties of limiglidole are beneficial in the treatment of diabetes mellitus.
Status:
Investigational
Source:
NCT01568229: Phase 2 Interventional Terminated Schizophrenia
(2012)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Tilapertin (also known as AMG 747) is a piperazineacetic acid derivative patented by Amgen Inc as glycine transporter-1 inhibitor useful for the treatment of negative symptoms of schizophrenia. Oral administration of AMG 747 dose-dependently increases cerebrospinal fluid(CSF) glycine concentration in rats. In humans, Tilapertin has linear pharmacokinetics, prolonged half-life, and acceptable safety and tolerability at multiple doses up to 60 mg daily dosing. Unfortunately, in clinical trials, Tilapertin failed to demonstrate superior efficacy compare antipsychotic therapy in clinically stable people with schizophrenia.
Status:
Investigational
Source:
NCT01903824: Phase 1 Interventional Completed Cognitive Impairment
(2013)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
IRDABISANT is a histamine H3 receptor inverse agonist with potential therapeutic utility in cognition enhancement.
Status:
Investigational
Source:
NCT00083252: Phase 2 Interventional Completed Melanoma
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Talabostat is a prolineboronate ester derivative patented by Boehringer Ingelheim Pharmaceuticals, Inc. as an antineoplastic agent. Talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. Talabostat has been shown to cause caspase-1 activation and IL-1β induction in macrophages, which in turn causes upregulation of the cytokines and chemokines that characterize the responses to talabostat, both in vitro and in tumor-bearing mice. Talabostat may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. In clinical trials, the combination of talabostat and cisplatin was well tolerated compared to historical data using cisplatin alone. The most frequent adverse events were nausea, vomiting, fatigue, anemia, edema, and constipation. Unfortunately was no evidence that Talabostat enhanced the clinical activity of other anticancer drugs and further development was discontinued.
Class (Stereo):
CHEMICAL (UNKNOWN)
Talisomycin (former trivial name: tallysomycin A), a third generation bleomycin analog that was studied as an antitumor antibiotic. The drug cleaved DNA preferentially at G-C and G-T sequences and produced specific cleavages at G-A sequences. Talisomycin participated in phase II clinical trial for the treatment of cancer; however, the further development of the drug was discontinued.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Tarazepide is a cholecystokinin-A receptor (CCK-A) receptor antagonist that was studied as an antispasmodic agent. However, information about the current use of this drug is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Atocalcitol is a vitamin D analogue. A hallmark of vitamin D3 analogues in psoriasis amelioration is the ability to inhibit the proliferation of keratinocytes. Atocalcitol had been in phase II clinical trials for the treatment of psoriasis. However, this research has been discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Brosotamide is organic compound useful as sedative, muscle-relaxing, antipyretic, choleretic, and analgesic agents
Class (Stereo):
CHEMICAL (ACHIRAL)
BROTIANIDE is salicylanilide derivative used to treat fascioliasis in sheep. A dose of 7 mg/kg of brotianide shows 91-99% activity against 7-14 weeks old flukes; however, its activity against 6 weeks old flukes is weak (50-90%). It also possesses 85-90% activity against paramphistomes in sheep and cattle. The maximum tolerated dose of brotianide is 27 mg/kg in sheep.
Status:
Investigational
Source:
INN:emprumapimod [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
