TARAZEPIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H24N4O2
Molecular Weight	448.5158
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(C=CC=C2)C(=N[C@H](NC(=O)C3=CC4=C5N3CCCC5=CC=C4)C1=O)C6=CC=CC=C6

InChI

InChIKey=CZPILLBHPRAPCB-AREMUKBSSA-N

InChI=1S/C28H24N4O2/c1-31-22-15-6-5-14-21(22)24(18-9-3-2-4-10-18)29-26(28(31)34)30-27(33)23-17-20-12-7-11-19-13-8-16-32(23)25(19)20/h2-7,9-12,14-15,17,26H,8,13,16H2,1H3,(H,30,33)/t26-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C28H24N4O2
Molecular Weight	448.5158
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9879754 | https://www.genome.jp/dbget-bin/www_bget?D02710

Tarazepide is a cholecystokinin-A receptor (CCK-A) receptor antagonist that was studied as an antispasmodic agent. However, information about the current use of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro.	2004-04	15009505
CCK regulates pancreatic enzyme secretion via short duodenal-pancreatic reflexes in pigs.	2003-02	12678338
Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide.	2000-03-10	10699709
Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves.	1998-11-30	9879754

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:16:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:16:18 GMT 2025`
Record UNII	RK2972YZ2U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

tarazepide [INN]

Preferred Name

English

TARAZEPIDE

Official Name

English

4H-Pyrrolo[3,2,1-ij]quinoline-2-carboxamide, N-[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-5,6-dihydro-

Systematic Name

English

N-[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxamide

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C547