BROTIANIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H10Br2ClNO2S
Molecular Weight	463.571
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)OC1=C(Br)C=C(Cl)C=C1C(=S)NC2=CC=C(Br)C=C2

InChI

InChIKey=NRFGEDASJHBPPN-UHFFFAOYSA-N

InChI=1S/C15H10Br2ClNO2S/c1-8(20)21-14-12(6-10(18)7-13(14)17)15(22)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,22)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3218049 | https://www.ncbi.nlm.nih.gov/pubmed/1211790 | https://www.ncbi.nlm.nih.gov/pubmed/9265850 | https://www.sciencedirect.com/science/article/pii/S0165720897800311

BROTIANIDE is salicylanilide derivative used to treat fascioliasis in sheep. A dose of 7 mg/kg of brotianide shows 91-99% activity against 7-14 weeks old flukes; however, its activity against 6 weeks old flukes is weak (50-90%). It also possesses 85-90% activity against paramphistomes in sheep and cattle. The maximum tolerated dose of brotianide is 27 mg/kg in sheep.

Originator

Approval Year

PubMed

Title	Date	PubMed
Treatment of Dicrocoelium dendriticum with a combination of thiophanate and brotianide.	1988 Dec 17	3218049

Patents

Sample Use Guides

In Vivo Use Guide

A dose of 7 mg/kg of brotianide shows 91-99% activity against 7-14 weeks old flukes; The maximum tolerated dose of brotianide is 27 mg/kg in sheep

Route of Administration: Oral

Name

Type

Language

BROTIANIDE

Official Name

English

3,4'DIBROMO-5-CHLOROTHIOSALICYLANILIDE ACETATE (ESTER)

Common Name

English

brotianide [INN]

Common Name

English

FBA-4059

Code

English

BROTIANIDE [MART.]

Common Name

English

BAY 4059 VA

Code

English

FBA 4059

Code

English

BAY-4059-VA

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C250