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Restrict the search for
aminosalicylic acid
to a specific field?
Status:
Investigational
Source:
NCT00514501: Phase 2 Interventional Completed Acute Coronary Syndrome
(2007)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Iodofiltic Acid I-123 is a single-photon branching free fatty acid radiopharmaceutical with potential application in single-photon emission computed tomography (SPECT). Assessment of fatty acid metabolism by radionuclide techniques has a potential role for the early detection of myocardial ischaemia and the assessment of the severity of ischaemic heart disease. The Iodofiltic Acid I-123 scan is preferable because it can provide suitable information for risk stratification just after an acute myocardial infarction (AMI) without requiring the patient to exercise; it can also detect previous ischaemic insult even after recovery of myocardial perfusion, the so- called "ischaemic memory".
Class (Stereo):
CHEMICAL (ACHIRAL)
ISOCROMIL, a chromone, is an antiallergic agent. It is a mediator release inhibitor used for the treatment of passive cutaneous anaphylaxis and as an anti-asthmatic.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Dexpemedolac is long-acting non-narcotic analgesic. Dexpemedolac exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. Dexpemedolac differed from standard nonsteroidal anti-inflammatory drugs (NSAIDs) in that the doses, which produced analgesia were much lower than those required for either anti-inflammatory or gastric irritant effects. The common to the NCAIDs class actions are antipyresis and inhibitory effects on platelet aggregation. In yeast-induced hyperthermic rats, dexpemedolac exhibited antipyretic actions, whereas the drug did not affect body temperature in normothermic animals. Aggregation of human platelets was inhibited by high concentrations of dexpemedolac.
Status:
Investigational
Source:
INN:fencibutirol [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Fencibutirol is alpha-cyclohexylbutyric acid derivative. It exerts choleretic activity.
Class (Stereo):
CHEMICAL (ACHIRAL)
IRLOXACIN, a fluorinated quinolone derivative, is an antibacterial agent with proved activity against both gram-positive and gram-negative bacteria.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Adekalant (H 345/52) is a new antiarrhythmic compound with low proarrhythmic activity. H 345/52 concentration-dependently blocked HERG-carried currents with an IC50 of 230 nM. H 345/52 preferentially bound to the open channel with unusually rapid kinetics and was trapped by channel closure. Voltage-independent behavior of H 345/52 was observed during both square-pulse and action potential clamp protocols. It is proposed that block of IKr is the principal mechanism by which H 345/52 delays repolarization in human myocardium. H 345/52 blocks I(Kr) with high potency and I(Ca) with somewhat lower potency and was found to delay ventricular repolarisation without substantially increasing temporal or spatial dispersion and without inducing early after-depolarisations or TdP.
Class (Stereo):
CHEMICAL (ACHIRAL)
Iosumetic Acid is a triiodoaminoisophthalic acid derivative patented by Schering A.-G. as contrast medium for direct and indirect lymphography.
Class (Stereo):
CHEMICAL (ACHIRAL)
Iotrizoic Acid is acylated amino acid derivative patented by Swiss pharmaceutical company Cilag-Chemie A.-G. as x-ray contrasting agent
Status:
Investigational
Source:
NCT00533377: Phase 2 Interventional Completed Tibial Fractures
(2008)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Evatanepag (CP-533,536) is a prostaglandin E2 EP2 receptor agonist. It stimulates new bone formation on trabecular, endocortical, and periosteal surfaces and enhances fracture healing. Evatanepag was under development with Pfizer as a bone formation stimulant for therapeutic use in the healing of fractures.
Class (Stereo):
CHEMICAL (ACHIRAL)
Iobutoic Acid is a Triiodo-hydroxybenzamide derivative patented by Laboratoires Andre Guerbet as x-ray contrast media in cholecystography and as a choleretic agent.
