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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H23NO3
Molecular Weight 349.4229
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXPEMEDOLAC

SMILES

CC[C@@]1(CC(O)=O)OC[C@H](CC2=CC=CC=C2)C3=C1NC4=C3C=CC=C4

InChI

InChIKey=BUUODSZYUAZDIF-AOMKIAJQSA-N
InChI=1S/C22H23NO3/c1-2-22(13-19(24)25)21-20(17-10-6-7-11-18(17)23-21)16(14-26-22)12-15-8-4-3-5-9-15/h3-11,16,23H,2,12-14H2,1H3,(H,24,25)/t16-,22-/m0/s1

HIDE SMILES / InChI

Description

Dexpemedolac is long-acting non-narcotic analgesic. Dexpemedolac exhibited potent analgesic effects against chemically induced pain in rats and mice and against inflammatory pain in rats. Dexpemedolac differed from standard nonsteroidal anti-inflammatory drugs (NSAIDs) in that the doses, which produced analgesia were much lower than those required for either anti-inflammatory or gastric irritant effects. The common to the NCAIDs class actions are antipyresis and inhibitory effects on platelet aggregation. In yeast-induced hyperthermic rats, dexpemedolac exhibited antipyretic actions, whereas the drug did not affect body temperature in normothermic animals. Aggregation of human platelets was inhibited by high concentrations of dexpemedolac.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
10-20 mg per kg
Route of Administration: Oral