U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C22H35IO2
Molecular Weight 454.4177
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOFILTIC ACID I-123

SMILES

CC(CCCCCCCCCCCCC1=CC=C([123I])C=C1)CC(O)=O

InChI

InChIKey=NPCIWINHUDIWAV-NSYCNWAXSA-N
InChI=1S/C22H35IO2/c1-19(18-22(24)25)12-10-8-6-4-2-3-5-7-9-11-13-20-14-16-21(23)17-15-20/h14-17,19H,2-13,18H2,1H3,(H,24,25)/i23-4

HIDE SMILES / InChI

Molecular Formula C22H35IO2
Molecular Weight 454.4177
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Iodofiltic Acid I-123 is a single-photon branching free fatty acid radiopharmaceutical with potential application in single-photon emission computed tomography (SPECT). Assessment of fatty acid metabolism by radionuclide techniques has a potential role for the early detection of myocardial ischaemia and the assessment of the severity of ischaemic heart disease. The Iodofiltic Acid I-123 scan is preferable because it can provide suitable information for risk stratification just after an acute myocardial infarction (AMI) without requiring the patient to exercise; it can also detect previous ischaemic insult even after recovery of myocardial perfusion, the so- called "ischaemic memory".

Originator

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
111MBq
Route of Administration: Intravenous
Substance Class Chemical
Record UNII
0J7USQ749M
Record Status Validated (UNII)
Record Version