U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1761 - 1770 of 2893 results

Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(27)(viii) antimicrobial:personnel hand wash tribromsalan
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Tribromsalan (trade name Temasept IV) is a member of brominated salicylanilides chemical family. Was initially registered in 1964 manufactured by Hexcel Corporation, Sherwin Williams Chemicals. It is a pesticide type with antimicrobial and preservative features found its application in hard surfaces, laundry, textiles, and manufactured products. Types of tribromsalan formulations include solid, solutions, and sprays and its usual carrier is soap. Limited exposure is possible based on the registered uses of these products as disinfectants, laundry additives, textile preservatives, and manufactured products and do not include direct application to a food or feed crop. In 1974 FDA directed the removal of tribromsalan drug products from the market because it was found to make skin extrasensitive to light. For the same reason it was forbidden in Europe since the 1970s. Since 1982 the OTC topical antimicrobial drug products rulemaking was reopened and included tribromsalan in a list of antimicrobial OTC Drug Products. At present tribromsalan is considered an antiseptic active ingredient eligible for the OTC use as a consumer antiseptic hand and body wash drug product. It was reported that tribromsalan, inhibits NF-kappaB signaling via inhibition of IkappaBalpha phosphorylation with IC50 of 7.9 uM. This finding provides new information on activities and mechanisms of action that may suggest mechanisms of potential novel applications in cancer treatment of such drugs as tribromsalan.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(6)(ii)(A) cough/cold:nasal decongestant allyl isothiocyanate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Allyl isothiocyanate (AITC), also known as mustard oil, is one of the most common naturally occurring isothiocyanates, which occurs in many common cruciferous vegetables. Besides antimicrobial activity against a wide spectrum of pathogens, it showed anticancer activity in both cultured cancer cells and animal models, although the underlining mechanisms remain largely undefined. Allyl isothiocyanate is a TRPA1 and TRPV1 agonist and pungency and lachrymatory effects of Allyl isothiocyanate are mediated through the TRPA1 and TRPV1 ion channels. Allyl isothiocyanate irritates the mucous membranes and induces eczematous or vesicular skin reactions.
Dichlorophene is a halogenated phenolic compound that functions as a bacteriocide and fungicide in cosmetics. Dichlorophene was reported to be used in a total of five cosmetic formulations at concentrations of 0% to 1.0%. Dichlorophen is used in the treatment of tapeworm infestation in man and animals and is the basis of a preparation against athlete’s foot. As a fungicide and bactericide it is recommended for the protection of textiles and materials including horticultural benches and equipment against moulds and algae.
Status:
US Previously Marketed
Source:
21 CFR 310.502(a) certain drugs dibromsalan
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dibromsalan (4',5-dibromosalicylanilide) is a disinfectant. Dibromsalan is a halogenated phenol derivative chemically related to bithionol and tetrachlorosalicylanilide (TCSA). It has antimicrobial properties. It was an ingredient of some commercial soaps. It was withdrawn from the market for reasons of safety. Dibromsalan was shown to cause photodermatitis.
Status:
Possibly Marketed Outside US
Source:
CFR:21 CFR 331.11
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

D-(-)-tartaric acid is isomer of tartaric acid, that industrially produced in the largest amounts. D-(-)-Tartaric acid may be used in the preparation of enantiospecific homochiral cis-4-formyl β-lactams. It may also be used as a starting material in the synthesis of D-erythro-sphingosine and L-lyxo-phytosphingosine. D-(-)-tartaric acid is widely used as an acidizing agent for beverages and other foods, and this use is similar to citric acid. Tartaric acid can be used as an acid dye mordant when it is combined with tannin. It is also used for some development and fixing operations in the photographic industry. D-(-)-Tartaric Acid is used in the preparation of synthetic analgesics. Tartaric acid is metabolically inert in the human body. When taken by mouth, only about 20% of ingested tartrate is eliminated in the urine; the remainder is not absorbed as such since it is destroyed in the intestinal tract by bacterial action. Sodium tartrate in daily doses of up to 10 or even 20 g has been used in medical practice as a laxative.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Class (Stereo):
CHEMICAL (ACHIRAL)

Methylcyclopentenolone (also known as methyl cyclopentenolone), a flavor compound that is used in the standard olfactory acuity test in patients with smell disorders.

Showing 1761 - 1770 of 2893 results