U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C13H10Cl2O2
Molecular Weight 269.123
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICHLOROPHEN

SMILES

OC1=CC=C(Cl)C=C1CC2=CC(Cl)=CC=C2O

InChI

InChIKey=MDNWOSOZYLHTCG-UHFFFAOYSA-N
InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2

HIDE SMILES / InChI
Molecular Formula C13H10Cl2O2
Molecular Weight 269.123
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/15162836 and http://datasheets.scbt.com/sc-255083.pdf

Dichlorophene is a halogenated phenolic compound that functions as a bacteriocide and fungicide in cosmetics. Dichlorophene was reported to be used in a total of five cosmetic formulations at concentrations of 0% to 1.0%. Dichlorophen is used in the treatment of tapeworm infestation in man and animals and is the basis of a preparation against athlete’s foot. As a fungicide and bactericide it is recommended for the protection of textiles and materials including horticultural benches and equipment against moulds and algae.

CNS Activity

Originator

Craig, A.H.|Kleckner, A.L.|Brinker, W.O.|Platt, J.
3
Curator's Comment: Dichlorophen was shown by Craig and Kleckner (1946) and Brinkner and Platt (1946) to kill and digest tapeworms in the intestine of dogs.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 70.0 µM [IC50]
Inhibitor
8504
Inhibitor
8504
2-propanol-supported respiration of Entamoeba histolytica
3
Target ID: 2-propanol-supported respiration of Entamoeba histolytica
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Basic research
Unknown

Approved Use

Unknown
Curative
Basic research
Unknown

Approved Use

Unknown
Curative
Basic research
Unknown

Approved Use

Unknown
Curative
Basic research
Unknown

Approved Use

Unknown
Curative
Approved
8583
Mycota spray

Approved Use

For the treatment and prevention of athletes foot.

Launch Date

2002
Doses

Doses

DosePopulationAdverse events​
1 % 1 times / day single, topical
Studied dose
Dose: 1 %, 1 times / day
Route: topical
Route: single
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/18714544/
unhealthy, 29 years
Health Status: unhealthy
Age Group: 29 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/18714544/
Other AEs: Contact dermatitis...
Other AEs:
Contact dermatitis
Sources:
https://pubmed.ncbi.nlm.nih.gov/18714544/
360 g 1 times / day single, oral
Studied dose
Dose: 360 g, 1 times / day
Route: oral
Route: single
Dose: 360 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9168328/
healthy, 59 years
Health Status: healthy
Age Group: 59 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/9168328/
Other AEs: Death...
Other AEs:
Death
Sources:
https://pubmed.ncbi.nlm.nih.gov/9168328/
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Other AEs: Epigastric pain, Nausea...
Other AEs:
Epigastric pain
Nausea
Diarrhea
Disturbance of liver function tests
Injury to kidney
Rhabdomyolysis
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
AEs

AEs

AESignificanceDosePopulation
Contact dermatitis
1 % 1 times / day single, topical
Studied dose
Dose: 1 %, 1 times / day
Route: topical
Route: single
Dose: 1 %, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/18714544/
unhealthy, 29 years
Health Status: unhealthy
Age Group: 29 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/18714544/
Death
360 g 1 times / day single, oral
Studied dose
Dose: 360 g, 1 times / day
Route: oral
Route: single
Dose: 360 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/9168328/
healthy, 59 years
Health Status: healthy
Age Group: 59 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/9168328/
Diarrhea
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Disturbance of liver function tests
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Epigastric pain
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Injury to kidney
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Nausea
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Rhabdomyolysis
72 g 1 times / day single, oral
Studied dose
Dose: 72 g, 1 times / day
Route: oral
Route: single
Dose: 72 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
unhealthy, 74 years
Health Status: unhealthy
Age Group: 74 years
Sex: F
Sources:
https://pubmed.ncbi.nlm.nih.gov/23473463/
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY583178
https://www.001chemical.com/chem/97-23-4
3B Scientific (Wuhan) Corp
3B3-032688
http://www.3bsc.com/index/pro_info.php?id=53952
AA Blocks
AA00IMFM
https://www.aablocks.com/goods/Goods/detail?id=AA00IMFM
Aaron Chemicals
AR00IN7E
http://www.aaronchem.com/97-23-4
abcr GmbH
AB117899
http://www.abcr.com/shop/en/AB117899
Acadechem
ACDS-033118
http://www.acadechemical.com/product/107817
AHH Chemical co.,ltd
MT-30982
http://www.ahhchemical.com/product/MT-30982.html
AK Scientific, Inc. (AKSCI)
71230
http://www.aksci.com/item_detail.php?cat=71230
Alfa Aesar
A12640
https://www.alfa.com/en/catalog/A12640/
Alfa Chemistry
ACM97234
https://materials.alfachemic.com/product/2-2-methylenebis-4-chlorophenol-cas-97-23-4-337163.html
Angene
AGN-PC-0JK6F8
http://www.angenechemical.com/productshow/AGN-PC-0JK6F8.html
Aurora Fine Chemicals LLC
K02.118.416
http://online.aurorafinechemicals.com/info?ID=K02.118.416
Avantor Inc
101187-650
https://us.vwr.com/store/catalog/product.jsp?catalog_number=101187-650
BioSynth
W-100114
https://www.biosynth.com/en/products/chemical-intermediates/advanced-intermediates/products/W-100114.html
Chem Scene
CS-3867
http://www.chemscene.com/97-23-4.html
ChemMol
30100307
http://www.chemmol.com/chemmol/30100307.html
ChemMol
49426336
http://www.chemmol.com/chemmol/49426336.html
Chemspace
CSSB00016994760
https://chem-space.com/CSSB00016994760
eNovation Chemicals
D680496
https://www.enovationchem.com/ProductDetails.asp?ProductID=D680496
eNovation Chemicals
Y1054510
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1054510
Finetech
FT-0609137
http://www.finetechnology-ind.com/prod/detail/pub/97-23-4.html
Finetech
FT-0739351
http://www.finetechnology-ind.com/prod/detail/pub/1322-43-6.html
FondChemical
FDB-2823
http://www.fondchemical.com/cpshow_cid_8_pid_2110.html
Glentham Life Sciences
GA7442
http://www.glentham.com/products/product/GA7442/
Hairui
HR132301
http://www.hairuichem.com/en/product/97-23-4.html
iChemical
EBD13780
http://www.ichemical.com/products/97-23-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
LGC Standards
DRE-C12440000
https://www.lgcstandards.com/US/en/p/DRE-C12440000
mcule
MCULE-2962145672
https://mcule.com/MCULE-2962145672/
MedChem Express
HY-12638
https://www.medchemexpress.com/Dichlorophen.html
Molcore
MC583178
https://www.molcore.com/product/97-23-4
MuseChem
I005711
https://www.musechem.com/product/I005711.html
Parchem
30289
https://www.parchem.com/chemical-supplier-distributor/Dichlorophene-030289.aspx
Parchem
Dichlorophene
http://www.parchem.com/chemical-supplier-distributor/Dichlorophene-030289.aspx
Sigma-Aldrich
133221_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/133221?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
35992_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/35992?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
373982_ALDRICH
https://www.sigmaaldrich.com/catalog/product/aldrich/373982?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S017461
http://www.sinfoobiotech.com/product/1020859
Smolecule
S525957
http://www.smolecule.com/products/s525957
TCI (Tokyo Chemical Industry)
M0213
http://www.tcichemicals.com/eshop/en/us/commodity/M0213/index.html
THE BioTek
bt-267719
https://www.thebiotek.com/product/inhibitors/bt-267719
PubMed

PubMed

TitleDatePubMed
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
2011-03-28
Profiles and some initial identifications of (anti)androgenic compounds in fish exposed to wastewater treatment works effluents.
2010-02-01
Fate of organohalogens in US wastewater treatment plants and estimated chemical releases to soils nationwide from biosolids recycling.
2009-12
The old and new therapeutic approaches to the treatment of giardiasis: where are we?
2009
Late patch test reaction to dichlorophene.
2008
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006-11
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
2004-05
Safety assessment of dichlorophene and chlorophene.
2004
Acute fatal poisoning with dichlorophen.
1997
Wheezing in a commercial diver due to disinfectant.
1991-07
[Allergy to preservatives].
1982
A Comparative Study of Hymenolepicides in Hymenolepis Mana Infestation of Rats.
1962-07
Patents

Patents

06248781
4
JPH08157306A
3

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Can also be applied topically for treatment of Athlete’s Foot https://imedi.co.uk/mycota-spray
A dose of 5 g is given usually in the morning to treat cestode infections
Route of Administration: Oral
In Vitro Use Guide
0.93 mM dichlorophene killed T. vaginalis within 24 hours in Asami media, Trophozoites of G. lamblia and T. vaginalis were killed in shorter than 10 min with 0.074 mM dichlorophene in serum-free media.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:35:02 GMT 2025
Edited
by admin
on Mon Mar 31 17:35:02 GMT 2025
Record UNII
T1J0JOU64O
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DICHLOROPHEN
HSDB   INN   ISO   MART.   MI   WHO-DD  
INN  
Official Name English
DICHLOROPHENE
GREEN BOOK   INCI  
INCI  
Preferred Name English
DIDROXANE
Brand Name English
DICHLOROPHEN [MART.]
Common Name English
dichlorophen [INN]
Common Name English
Dichlorophen [WHO-DD]
Common Name English
4,4'-DICHLORO-2,2'-METHYLENEDIPHENOL
Systematic Name English
G-4
Code English
PARABIS
Brand Name English
DICHLOROPHEN [ISO]
Common Name English
2,2'-METHYLENEBIS(4-CHLOROPHENOL)
Systematic Name English
DICHLOROPHENE [GREEN BOOK]
Common Name English
5,5'-DICHLORO-2,2'-DIHYDROXYDIPHENYLMETHANE
Common Name English
ANTHIPHEN
Brand Name English
DICHLOROPHEN [HSDB]
Common Name English
NSC-38642
Code English
DICHLOROPHEN [MI]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 55001
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
CFR 21 CFR 176.170
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
NCI_THESAURUS C250
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
WHO-ATC P02DX02
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
WHO-VATC QP52AG01
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
CFR 21 CFR 520.580
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
CFR 21 CFR 520.581
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
Code System Code Type Description
DRUG BANK
DB11396
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
INN
674
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
ALANWOOD
dichlorophen
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
ChEMBL
CHEMBL33845
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
SMS_ID
100000082933
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
NSC
38642
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
DRUG CENTRAL
863
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PRIMARY
MERCK INDEX
m4351
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY Merck Index
HSDB
6033
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PRIMARY
ECHA (EC/EINECS)
202-567-1
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PRIMARY
NCI_THESAURUS
C47485
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PRIMARY
CAS
97-23-4
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
FDA UNII
T1J0JOU64O
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
RXCUI
3351
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
DICHLOROPHEN
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
MESH
D004003
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PRIMARY
EVMPD
SUB07085MIG
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PRIMARY
PUBCHEM
3037
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
EPA CompTox
DTXSID6021824
Created by admin on Mon Mar 31 17:35:02 GMT 2025 , Edited by admin on Mon Mar 31 17:35:02 GMT 2025
PRIMARY
Related Record Type Details
Structure of DICHLOROPHEN DISODIUM
SALT/SOLVATE -> PARENT
Structure of DICHLOROPHEN MONOSODIUM
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of DICHLOROPHEN
ACTIVE MOIETY
NIH
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