DIBROMSALAN

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H9Br2NO2
Molecular Weight	371.024
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(C=C(Br)C=C1)C(=O)NC2=CC=C(Br)C=C2

InChI

InChIKey=CTFFKFYWSOSIAA-UHFFFAOYSA-N

InChI=1S/C13H9Br2NO2/c14-8-1-4-10(5-2-8)16-13(18)11-7-9(15)3-6-12(11)17/h1-7,17H,(H,16,18)

HIDE SMILES / InChI

Molecular Formula	C13H9Br2NO2
Molecular Weight	371.024
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14494462 | https://www.ncbi.nlm.nih.gov/pubmed/14494462 | https://www.ncbi.nlm.nih.gov/pubmed/5910875

Dibromsalan (4',5-dibromosalicylanilide) is a disinfectant. Dibromsalan is a halogenated phenol derivative chemically related to bithionol and tetrachlorosalicylanilide (TCSA). It has antimicrobial properties. It was an ingredient of some commercial soaps. It was withdrawn from the market for reasons of safety. Dibromsalan was shown to cause photodermatitis.

Approval Year

Doses

Dose	Population	Adverse events
1 % 1 times / day single, topical Studied dose Dose: 1 %, 1 times / day Route: topical Route: single Dose: 1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5910875/	healthy, mean age 55.5 years n = 2 Health Status: healthy Age Group: mean age 55.5 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/5910875/	Other AEs: Photosensitive dermatitis... Other AEs: Photosensitive dermatitis Sources: https://pubmed.ncbi.nlm.nih.gov/5910875/

AEs

AE	Significance	Dose	Population
Photosensitive dermatitis		1 % 1 times / day single, topical Studied dose Dose: 1 %, 1 times / day Route: topical Route: single Dose: 1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/5910875/	healthy, mean age 55.5 years n = 2 Health Status: healthy Age Group: mean age 55.5 years Sex: M+F Population Size: 2 Sources: https://pubmed.ncbi.nlm.nih.gov/5910875/

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L24NL
Aurora Fine Chemicals LLC	A23.240.621	http://online.aurorafinechemicals.com/info?ID=A23.240.621
BOC Sciences	87-12-7	https://www.bocsci.com/dibromsalan-cas-87-12-7-item-139937.html
Chemieliva Pharmaceutical Co., Ltd	PBCM0000239
Chemspace	CSC000597839
Compound Cloud	14839
Enamine	BBV-57845578
Enamine	PV-001820996608
HongKong Chemhere	SCA07183
NCI Plated 2007	20527
NovoSeek	14839
Otava	1016510
Selena	SEL13822843
THE BioTek	bt-433654	https://www.thebiotek.com/product/others/bt-433654
Tetrahedron	TS80016
ZINC	ZINC000000608319	http://zinc15.docking.org/substances/ZINC000000608319
eMolecules	110043151

PubMed

Title	Date	PubMed
Relationship between the structure and antimycobacterial activity of substituted salicylanilides.	2003 Mar	12666254

Sample Use Guides

In Vivo Use Guide

The 0.5% dibromsalan was applied to one forearm

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:18 GMT 2023` Edited by `admin` on `Fri Dec 15 14:59:18 GMT 2023`
Record UNII	N9900K2RBT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIBROMSALAN

Official Name

English

SALICYLANILIDE, 4',5-DIBROMO-

Systematic Name

English

DBS

Common Name

English

NSC-20527

Code

English

DIBROMSALAN [MART.]

Common Name

English

4',5-DIBROMOSALICYLANILIDE

Systematic Name

English

DIBROMSALAN [USAN]

Common Name

English

Dibromsalan [WHO-DD]

Common Name

English

dibromsalan [INN]

Common Name

English

BENZAMIDE, 5-BROMO-N-(4-BROMOPHENYL)-2-HYDROXY-

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

77402