Propoxycaine hydrochloride is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. Propoxycaine Hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.

Hexylcaine hydrochloride, a benzoic acid ester, is a local anaesthetic that has been used for surface anaesthesia of mucous membranes. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.

Dimethisoquin (also known as Quinisocaine and QUOTANE) is a topical anesthetic used as an antipruritic. It was shown that dimethisoquin inhibits nicotinic acetylcholine receptors (alpha4/beta4 and alpha4/beta2) with the maximum inhibition potency occurring for the α4β4 subtype.

Metabutethamine hydrochloride was used as a local anesthetic.

Piridocaine is a piperidyl propanol ester of orthoaminobenzoic acid. The toxicity of this drug resembles that of procaine. It differs from procaine in that the minimum anesthetic dose is smaller, the minimal lethal dose larger, and duration of anesthesia longer. Subarachnoid piridocaine with and without epinephrine or ephedrine offers a simple and dependable means of obtaining any degree or extent of analgesia up to the third thoracic nerves without profound or widespread motor paralysis. The most promising clinical field of usefulness for piridocaine is obstetrics.

Cyclomethycaine (also known as Surfacaine) is a local anesthetic.

Cyclomethycaine (also known as Surfacaine) is a local anesthetic.

Amolanone (amethone) is a local anesthetic. It also has antispasmodic action.