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Details

Stereochemistry ACHIRAL
Molecular Formula C17H24N2O.ClH
Molecular Weight 308.846
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIMETHISOQUIN HYDROCHLORIDE

SMILES

Cl.CCCCC1=NC(OCCN(C)C)=C2C=CC=CC2=C1

InChI

InChIKey=SEYCAKMZVYADRS-UHFFFAOYSA-N
InChI=1S/C17H24N2O.ClH/c1-4-5-9-15-13-14-8-6-7-10-16(14)17(18-15)20-12-11-19(2)3;/h6-8,10,13H,4-5,9,11-12H2,1-3H3;1H

HIDE SMILES / InChI

Description

Dimethisoquin (also known as Quinisocaine and QUOTANE) is a topical anesthetic used as an antipruritic. It was shown that dimethisoquin inhibits nicotinic acetylcholine receptors (alpha4/beta4 and alpha4/beta2) with the maximum inhibition potency occurring for the α4β4 subtype.

Approval Year

1951
104
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L1NGJ
Alfa Chemistry
86-80-6
https://www.alfa-chemistry.com/cas_86-80-6.htm
Alinda
IBS-L0034129
Aurora Fine Chemicals LLC
A18.031.330
http://online.aurorafinechemicals.com/info?ID=A18.031.330
BOC Sciences
2773-92-4
ChemExper Chemical Directory
jbuQ@@LRAdbbRbTRTrnxjtZB@bBhh@@@
Chemieliva Pharmaceutical Co., Ltd
PBCM1442523
Chemspace
CSSS00025761702
https://chem-space.com/CSSS00025761702
Compound Cloud
6857
Compound Cloud
9883104
Hairui
HR101310
Innovapharm
VT-00687873
Lab Network
LN01203020
MolPort
MolPort-002-041-799
https://www.molport.com/shop/molecule-link/MolPort-002-041-799
MuseChem
M219312
MuseChem
R024056
Norris Pharm
NSZB-A092819
NovoSeek
6857
Princeton BioMolecular Research
OSSL_297013
Scientific Exchange
M-981981
Sigma Aldrich
R415189
Sigma Aldrich
R415189|ALDRICH
Smolecule
S591433
https://www.smolecule.com/products/s591433
Specs
AO-080/43342670
THE BioTek
bt-405547
https://www.thebiotek.com/product/others/bt-405547
TimTec
SBB116813
TimTec
ST076784
TimTec
ST50449263
ZINC
ZINC000001671507
http://zinc15.docking.org/substances/ZINC000001671507
eMolecules
1843646
eMolecules
299986846
eMolecules
629196
mcule
MCULE-8714132699
https://mcule.com/MCULE-8714132699/
PubMed

PubMed

TitleDatePubMed
Travell trigger points--molecular and osteopathic perspectives.
2004 Jun
[Synthetic antimalarials].
2005 Aug-Sep
Patents

Patents

JP2005513255A
2
JP2007195974A
8
JP2011528028A
2

Sample Use Guides

In Vivo Use Guide
To the skin as a 0.5% oinment or lotion 2 to 4 times per day.
Route of Administration: Topical
In Vitro Use Guide
Various local anesthetics enhanced the incorporation of [3H]inositol into phosphoinositides in guinea pig cerebral cortical synaptoneurosomes. Dibucaine, QX-572 and dimethisoquin showed maximum stimulation at 100 microM. There was no correlation between local anesthetic activity, estimated by inhibition of the 22Na+ flux elicited by the sodium channel activator batrachotoxin, and the potency for stimulation of inositol incorporation.
Name Type Language
DIMETHISOQUIN HYDROCHLORIDE
MI   USAN   USP-RS  
USAN  
Official Name English
DIMETHISOQUIN HYDROCHLORIDE [MI]
Common Name English
QUINISOCAINE HYDROCHLORIDE
MART.   WHO-DD  
Common Name English
3-Butyl-1-[2-(dimethylamino)ethoxy]isoquinoline monohydrochloride
Systematic Name English
DIMETHISOQUIN HYDROCHLORIDE [USAN]
Common Name English
ETHANAMINE, 2-((3-BUTYL-1-ISOQUINOLINYL)OXY)-N,N-DIMETHYL-, MONOHYDROCHLORIDE
Common Name English
DIMETHISOQUIN HCL
Common Name English
Quinisocaine hydrochloride [WHO-DD]
Common Name English
QUINISOCAINE HYDROCHLORIDE [MART.]
Common Name English
QUINISOCAINE HCL
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C245
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL127643
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
MESH
C009146
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
NCI_THESAURUS
C72742
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
PUBCHEM
17714
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
EVMPD
SUB04189MIG
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
MERCK INDEX
m1118
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY Merck Index
FDA UNII
SMP2689462
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
ECHA (EC/EINECS)
220-468-1
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID6045373
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
CAS
2773-92-4
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
SMS_ID
100000085250
Created by admin on Fri Dec 15 15:14:18 GMT 2023 , Edited by admin on Fri Dec 15 15:14:18 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of DIMETHISOQUIN
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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