Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H26N2O3.ClH |
Molecular Weight | 330.85 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCOC1=C(C=CC(N)=C1)C(=O)OCCN(CC)CC
InChI
InChIKey=GITPCGSPKUQZTE-UHFFFAOYSA-N
InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
Molecular Formula | C16H26N2O3 |
Molecular Weight | 294.3892 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://pubchem.ncbi.nlm.nih.gov/compound/11078
Sources: http://pubchem.ncbi.nlm.nih.gov/compound/11078
Propoxycaine hydrochloride is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. Propoxycaine Hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.
Approval Year
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
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OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
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Drug as perpetrator​
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
yes [Activation 1.99526 uM] | ||||
yes [Activation 12.58925 uM] |
PubMed
Title | Date | PubMed |
---|---|---|
Allergic contact dermatitis to proparacaine with subsequent cross-sensitization to tetracaine from ophthalmic preparations. | 2001 Sep |
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Systemic manifestations in response to mydriasis and physical examination during screening for retinopathy of prematurity. | 2004 Apr |
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Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs. | 2005 Jan |
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Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity. | 2005 Jun |
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Flap suturing with proparacaine for recurrent epithelial ingrowth following laser in situ keratomileusis surgery. | 2005 May |
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Efficacy of topical anesthetics to reduce pain in premature infants during eye examinations for retinopathy of prematurity. | 2005 May |
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Patient pain during stretching of small pupils in phacoemulsification performed using topical anesthesia. | 2005 Sep |
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Pupil dilation using a pledget sponge: a randomized controlled trial. | 2006 Aug |
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Contamination of single-use Minims eye drops by multiple use in clinics. | 2006 Feb |
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Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine. | 2006 Jan |
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Duration of corneal anesthesia following topical administration of 0.5% proparacaine hydrochloride solution in clinically normal cats. | 2006 Oct |
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Prospective randomized double-masked trial to evaluate perioperative pain profile in different stages of simultaneous bilateral LASIK. | 2006 Sep |
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Analgesic efficacy of single-dose parecoxib for corneal suturing in children. | 2007 May |
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Evaluation of duration of corneal anesthesia induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet aesthesiometer in clinically normal horses. | 2008 Dec |
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Adjustable suture strabismus surgery in infants and children. | 2008 Dec |
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Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. | 2009 Feb |
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An atypical presentation of acanthamoeba keratitis in a patient with keratoconus treated briefly with topical anesthetic. | 2009 Jan |
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Antibacterial activity of preservative-free topical anesthetic drops in current use in ophthalmology departments. | 2009 Jan |
|
Topical proparacaine and episcleral venous pressure in the rabbit. | 2009 Jun |
|
Ocular blood-flow hemodynamics before and after application of a laser in situ keratomileusis ring. | 2010 Feb |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:03:48 UTC 2023
by
admin
on
Fri Dec 15 16:03:48 UTC 2023
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Record UNII |
K490D39G46
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Record Status |
Validated (UNII)
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C245
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CHEMBL1195
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DBSALT001348
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SUB04089MIG
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760044
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11078
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DTXSID6045325
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m9220
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K490D39G46
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |