Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H26N2O3.ClH |
Molecular Weight | 330.85 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCOC1=C(C=CC(N)=C1)C(=O)OCCN(CC)CC
InChI
InChIKey=GITPCGSPKUQZTE-UHFFFAOYSA-N
InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
Molecular Formula | C16H26N2O3 |
Molecular Weight | 294.3892 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://pubchem.ncbi.nlm.nih.gov/compound/11078
Sources: http://pubchem.ncbi.nlm.nih.gov/compound/11078
Propoxycaine hydrochloride is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. Propoxycaine Hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.
Approval Year
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
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Drug as perpetrator​
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
no [Activation >10 uM] | ||||
yes [Activation 1.99526 uM] | ||||
yes [Activation 12.58925 uM] |
PubMed
Title | Date | PubMed |
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The efficacy of 0.5% proparacaine stored at room temperature. | 2001 Sep |
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Allergic contact dermatitis to proparacaine with subsequent cross-sensitization to tetracaine from ophthalmic preparations. | 2001 Sep |
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Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity. | 2005 Jun |
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Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine. | 2006 Jan |
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Anaesthetic abuse keratopathy as a manifestation of ocular Munchausen's syndrome. | 2006 Jan-Feb |
|
Prospective randomized double-masked trial to evaluate perioperative pain profile in different stages of simultaneous bilateral LASIK. | 2006 Sep |
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Topical anesthesia in transconjunctival sutureless 25-gauge vitrectomy for macular-based disorders. | 2007 |
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Cataract surgery complication rates. | 2008 Aug |
|
Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. | 2008 Aug |
|
Evaluation of duration of corneal anesthesia induced with ophthalmic 0.5% proparacaine hydrochloride by use of a Cochet-Bonnet aesthesiometer in clinically normal horses. | 2008 Dec |
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Adjustable suture strabismus surgery in infants and children. | 2008 Dec |
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Anterior sub-Tenon's anesthesia for the treatment of retinopathy of prematurity. | 2008 May-Jun |
|
Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation. | 2008 May-Jun |
|
A lacrimal sac abscess incision and drainage technique. | 2008 Sep |
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Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage. | 2008 Sep |
|
Intraoperative adjustable suture strabismus surgery under topical and subconjunctival anesthesia. | 2008 Sep-Oct |
|
Prolonged corneal anaesthesia by proxymetacaine hydrochloride detected by a thermal cooling stimulus. | 2009 Apr |
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Ring keratitis associated with topical abuse of a dilute anesthetic after refractive surgery. | 2009 Dec |
|
Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. | 2009 Feb |
|
An atypical presentation of acanthamoeba keratitis in a patient with keratoconus treated briefly with topical anesthetic. | 2009 Jan |
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Antibacterial activity of preservative-free topical anesthetic drops in current use in ophthalmology departments. | 2009 Jan |
|
Topical proparacaine and episcleral venous pressure in the rabbit. | 2009 Jun |
|
The reuse of ophthalmic minims: an unacceptable cross-infection risk? | 2010 Aug |
|
Light sensitivity and pain sensation during cataract surgery. A comparative study of two modes of anaesthesia. | 2010 Dec |
|
Pain management during eye examinations for retinopathy of prematurity in preterm infants: a systematic review. | 2010 Mar |
|
Dilute proparacaine for the management of acute corneal injuries in the emergency department. | 2010 Sep |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:03:48 GMT 2023
by
admin
on
Fri Dec 15 16:03:48 GMT 2023
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Record UNII |
K490D39G46
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Record Status |
Validated (UNII)
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C245
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11078
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |