U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1601 - 1610 of 1728 results

Silver iodide is an inorganic compound with the formula AgI. It is used as a photosensitive agent in photography, as a local antiseptic, as a chemical intermediate, and in cloud seeding for rain-making. The major hazards encountered in the use and handling of silver iodide stem from its toxicologic properties. Effects from exposure may include skin rashes, conjunctivitis, argyria (a permanent ashen-gray discoloration of skin, conjunctiva, and internal organs), headache, fever, hypersensitivity, laryngitis, and bronchitis.
Status:
US Previously Marketed
Source:
Corrosive Mercuric Chloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Corrosive Mercuric Chloride U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Potassium Triiodomercurate(II) is a periodometallate salt. It contains a triiodomercurate(1-). It is an antiseptic (topical) and disinfectant. It is also an antiseborrheic agent.
Status:
US Previously Marketed
Source:
Sodium Arsenate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Arsenate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Ammonium dihydrogen arsenate is an inorganic compound that has been considered a potential electro-optic material and has been explored by a number of investigators for modulation purposes. Ammonium arsenate is a cancerogenic substance.
Status:
US Previously Marketed
Source:
Cinchonine Sulphate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Cinchonine Sulphate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cinchonine is cinchona bark alkaloid, which was used to treat malaria. Cinchonine is more efficient than quinine in increasing the intracellular accumulation and restoring the cytotoxicity of doxorubicin, mitoxantrone and vincristine on well-characterized multidrug resistance (MDR) cell lines. In the phase I of clinical trial was investigated the properties of cinchonine combined with the CHVP (cyclophosphamide, doxorubicin, vinblastine, methylprednisolone) regimen in relapsed and refractory lymphoproliferative syndromes.
Acriflavine (ACF) is a topical antiseptic. The hydrochloride form is more irritating than the neutral form. It is derived from acridine. Commercial preparations are often mixtures with proflavine. Acriflavine was developed in 1912 by Paul Ehrlich, a German medical researcher, and was used during the First World War against sleeping sickness. ACF has known trypanocidal, antibacterial, and antiviral activities. Effects of ACF on cancer cells were first reported 50 years ago. By present time was demonstrated that ACF a drug, that binds directly to HIF-1 alpha and HIF-2 alpha and inhibits HIF-1 dimerization and transcriptional activity and thus has potent inhibitory effects on tumor growth and vascularization. Also Acriflavine in combination with 3,6-diaminoacridine (proflavine) could prove to be a potential antimalarial drug and its pharmacological action can be due to inhibition of gyrase activity. This is achieved through interaction of the ACF with the DNA substrate. This interaction may lead to conformation change in DNA unsuitable for binding of gyrase with DNA.
Proflavine is an acriflavine derivative used as a topical disinfectant agains gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds. Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. Proflavine was investigated for photodynamic theraphy of herpes but was discontinued due to several presentations of post-treatment Bowen's disease and higher lesion recrudescence periods. Proflavine is also investigated as a topical contrast agent for imaging and diagnosis of esophageal, oral, colon, cervical, uterine cancer and polyps.
Proflavine is an acriflavine derivative used as a topical disinfectant agains gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds. Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. Proflavine was investigated for photodynamic theraphy of herpes but was discontinued due to several presentations of post-treatment Bowen's disease and higher lesion recrudescence periods. Proflavine is also investigated as a topical contrast agent for imaging and diagnosis of esophageal, oral, colon, cervical, uterine cancer and polyps.
Proflavine is an acriflavine derivative used as a topical disinfectant agains gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds. Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. Proflavine was investigated for photodynamic theraphy of herpes but was discontinued due to several presentations of post-treatment Bowen's disease and higher lesion recrudescence periods. Proflavine is also investigated as a topical contrast agent for imaging and diagnosis of esophageal, oral, colon, cervical, uterine cancer and polyps.
Status:
US Previously Marketed
Source:
ACTILAMIDE CHLORAMINE T by BROEMMEL
(1961)
Source URL:
First marketed in 1916

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Tosylchloramide or N-chloro tosylamide, sodium salt, sold as chloramine-T, is an investigational animal drug used in the aquaculture industry and also is a very effective odor control compound. It has other applications that include: algaecide, bactericide, germicide, parasite control, and for drinking water disinfection. It is also highly effective against bacteria, viruses, and spores. In the aquaculture and aquafarming industries, Chloramine -T (Tosylchloramide Sodium Salt) is used to treat external bacterial infections in salmonid fish such as koi, salmon, trout, and whitefish. In the personal care industry, it is used in hydrotherapy treatments to revitalize, maintain, and restore health. Hydrotherapeutic applications include whirlpools, saunas, steam baths, foot baths, and sitz baths. Chloramine-T is also used for disinfection in saunas, solariums, gyms, sport centres, kitchens, sanitary facilities, and air conditioning units. As an anti-microbial agent,Chloramine-T (Tosylchloramide Sodium Salt) it has had widespread use in a broad range of practices, including medical, dental, verterinary food processing and agricultural. It also has been used in direct contact with tissues because it has a low degree of cytotoxicity. Within the United States of America, the use of Chloramine-T is more restricted. Disifin (Tosylchloramide) destroys DNA and thereby prevents microbes from. DISIFIN® Tablets are effective against a whole series of microorganisms, including grampositive and gram-negative bacteria, enveloped and non-en reproducing.
Status:
US Previously Marketed
Source:
ACTILAMIDE CHLORAMINE T by BROEMMEL
(1961)
Source URL:
First marketed in 1916

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Tosylchloramide or N-chloro tosylamide, sodium salt, sold as chloramine-T, is an investigational animal drug used in the aquaculture industry and also is a very effective odor control compound. It has other applications that include: algaecide, bactericide, germicide, parasite control, and for drinking water disinfection. It is also highly effective against bacteria, viruses, and spores. In the aquaculture and aquafarming industries, Chloramine -T (Tosylchloramide Sodium Salt) is used to treat external bacterial infections in salmonid fish such as koi, salmon, trout, and whitefish. In the personal care industry, it is used in hydrotherapy treatments to revitalize, maintain, and restore health. Hydrotherapeutic applications include whirlpools, saunas, steam baths, foot baths, and sitz baths. Chloramine-T is also used for disinfection in saunas, solariums, gyms, sport centres, kitchens, sanitary facilities, and air conditioning units. As an anti-microbial agent,Chloramine-T (Tosylchloramide Sodium Salt) it has had widespread use in a broad range of practices, including medical, dental, verterinary food processing and agricultural. It also has been used in direct contact with tissues because it has a low degree of cytotoxicity. Within the United States of America, the use of Chloramine-T is more restricted. Disifin (Tosylchloramide) destroys DNA and thereby prevents microbes from. DISIFIN® Tablets are effective against a whole series of microorganisms, including grampositive and gram-negative bacteria, enveloped and non-en reproducing.

Showing 1601 - 1610 of 1728 results