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Details

Stereochemistry ACHIRAL
Molecular Formula C7H7ClNO2S.Na.3H2O
Molecular Weight 281.69
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORAMINE-T TRIHYDRATE

SMILES

O.O.O.[Na+].CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl

InChI

InChIKey=NZYOAGBNMCVQIV-UHFFFAOYSA-N
InChI=1S/C7H7ClNO2S.Na.3H2O/c1-6-2-4-7(5-3-6)12(10,11)9-8;;;;/h2-5H,1H3;;3*1H2/q-1;+1;;;

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H8ClNO2S
Molecular Weight 205.662
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tosylchloramide or N-chloro tosylamide, sodium salt, sold as chloramine-T, is an investigational animal drug used in the aquaculture industry and also is a very effective odor control compound. It has other applications that include: algaecide, bactericide, germicide, parasite control, and for drinking water disinfection. It is also highly effective against bacteria, viruses, and spores. In the aquaculture and aquafarming industries, Chloramine -T (Tosylchloramide Sodium Salt) is used to treat external bacterial infections in salmonid fish such as koi, salmon, trout, and whitefish. In the personal care industry, it is used in hydrotherapy treatments to revitalize, maintain, and restore health. Hydrotherapeutic applications include whirlpools, saunas, steam baths, foot baths, and sitz baths. Chloramine-T is also used for disinfection in saunas, solariums, gyms, sport centres, kitchens, sanitary facilities, and air conditioning units. As an anti-microbial agent,Chloramine-T (Tosylchloramide Sodium Salt) it has had widespread use in a broad range of practices, including medical, dental, verterinary food processing and agricultural. It also has been used in direct contact with tissues because it has a low degree of cytotoxicity. Within the United States of America, the use of Chloramine-T is more restricted. Disifin (Tosylchloramide) destroys DNA and thereby prevents microbes from. DISIFIN® Tablets are effective against a whole series of microorganisms, including grampositive and gram-negative bacteria, enveloped and non-en reproducing.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Tosylchloramide sodium

Approved Use

The proposed indication for horses is skin desinfection, especially treatment of phlegmone (cellulitis).
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
Tox targets

Tox targets

Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro.
2007 Jun
Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver.
2017 Aug
Patents

Sample Use Guides

Rats were treated orally with chloramine-T at doses of 1.25, 2.50, 5 and 10 mg/kg body weight (bw)/day for 6 days. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increased after treatment with 2.50, 5 and 10 mg/kg bw/day, in a dose-dependent manner as compared to control. This effect was not observed after chloramine-T treatment at dose of 1.25 mg/kg bw/day.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: In vitro study of various concentrations and exposure times to preparations containing human fibroblasts or 1.5 x 10 colony forming units per milliliter (CFU/mL) of 3 gram-positive bacteria-Staphylococcus aureus, methicillin-resistant S aureus, and vancomycin-resistant Enterococcus faecalis-and 2 gram-negative bacteria-Escherichia coli and Pseudomonas aeruginosa-with and without fetal bovine serum present.
Gram-positive growth is reduced by 95% to 100% after tosylchloramide treatment, regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. In vitro, chloramine-T at 200 ppm for 5 to 20 minutes was effective against 3 virulent gram-positive bacteria without fibroblast damage. At 300 ppm and 3 and 5 minutes, 30% of fibroblasts were damaged and 95% to 100 % of E coli were inhibited, respectively.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:07:54 GMT 2023
Edited
by admin
on Fri Dec 15 15:07:54 GMT 2023
Record UNII
4IU6VSV0EI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORAMINE-T TRIHYDRATE
MI  
Common Name English
HALAMID
Brand Name English
N-CHLORO-P-TOLUENESULFONAMIDE, MONOSODIUM SALT, TRIHYDRATE
Common Name English
MINACHLOR
Brand Name English
CHLORAMINE-T TRIHYDRATE [GREEN BOOK]
Common Name English
CHLORASEPTIN
Brand Name English
CLORINA
Brand Name English
CHLORAMINE-T TRIHYDRATE [MI]
Common Name English
TRICHLOROL
Systematic Name English
BENZENESULFONAMIDE, N-CHLORO-4-METHYL-, SODIUM SALT, HYDRATE (1:1:3)
Systematic Name English
EUCLORINA
Brand Name English
CHLORAZENE
Brand Name English
TOSYLCHLORAMIDE SODIUM TRIHYDRATE
Systematic Name English
DISIFIN
Brand Name English
SODIUM DERIVATIVE OF N-CHLORO-P-TOLUENESULFONAMIDE TRIHYDRATE
Common Name English
HYDROCLONAZONE
Brand Name English
CHLORAMINE-T
Common Name English
CHLORAZOL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
CFR 21 CFR 556.118
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
Code System Code Type Description
RXCUI
1592902
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
CHEBI
53767
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
MERCK INDEX
m3345
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID6040795
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
PUBCHEM
517414
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
DRUG BANK
DBSALT002810
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
DAILYMED
4IU6VSV0EI
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
RXCUI
20762
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
ALTERNATIVE
MESH
C016300
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
CAS
7080-50-4
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
NCI_THESAURUS
C77036
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
ChEMBL
CHEMBL1625750
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
FDA UNII
4IU6VSV0EI
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
WIKIPEDIA
CHLORAMINE-T
Created by admin on Fri Dec 15 15:07:54 GMT 2023 , Edited by admin on Fri Dec 15 15:07:54 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY