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Details

Stereochemistry ACHIRAL
Molecular Formula Ag.NO3
Molecular Weight 169.8731
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILVER NITRATE

SMILES

[Ag+].[O-][N+]([O-])=O

InChI

InChIKey=SQGYOTSLMSWVJD-UHFFFAOYSA-N
InChI=1S/Ag.NO3/c;2-1(3)4/q+1;-1

HIDE SMILES / InChI
Molecular Formula Ag
Molecular Weight 107.8682
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula NO3
Molecular Weight 62.0049
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/monograph/silver-nitrate.html | https://www.ncbi.nlm.nih.gov/pubmed/18245232

Silver iodide is an inorganic compound with the formula AgI. It is used as a photosensitive agent in photography, as a local antiseptic, as a chemical intermediate, and in cloud seeding for rain-making. The major hazards encountered in the use and handling of silver iodide stem from its toxicologic properties. Effects from exposure may include skin rashes, conjunctivitis, argyria (a permanent ashen-gray discoloration of skin, conjunctiva, and internal organs), headache, fever, hypersensitivity, laryngitis, and bronchitis.

Originator

Orisheva, R.M.|Nechepurenko, Yu.V.|Sokolov, V.G.
16
Sources: Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk, Issue 2, Pages 69-73, Journal, 1990https://www.ncbi.nlm.nih.gov/pubmed/20429870
Curator's Comment: The medical uses of silver date back to at least the time of Hippocrates

Approval Year

1921
1468
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Approved
8583
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Phase I
438
Unknown

Approved Use

Unknown
Curative
Not Provided
511
Unknown

Approved Use

Unknown
Curative
Not Provided
511
Unknown

Approved Use

Unknown
Primary
Not Provided
511
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Primary
Not Provided
511
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Palliative
Approved
8583
Unknown

Approved Use

Antiseptic Wound Cauterization
Primary
Approved
8583
Unknown

Approved Use

Prophylaxis of gonococcal ophthalmia neonatorum. AAP recommends use of topical silver nitrate, povidone-iodine, or possibly erythromycin for prophylaxis of nongonococcal nonchlamydial conjunctivitis in neonates, ideally administered shortly after birth.
PubMed

PubMed

TitleDatePubMed
Directional growth of Ag nanorod from polymeric silver cyanide: A potential substrate for concentration dependent SERS signal enhancement leading to melamine detection.
2017-08-05
The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.
2017-05-08
UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.
2016-01
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care.
2015-12-22
A novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione.
2014-04-22
Development of silica-coated silver iodide nanoparticles and their biodistribution.
2012-12
Cleaning and decontamination efficacy of wiping cloths and silver dihydrogen citrate on food contact surfaces.
2012-07
Topical antimicrobials for burn wound infections.
2010-06
Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli.
2008-04
Photocatalytic degradation of pathogenic bacteria with AgI/TiO2 under visible light irradiation.
2007-04-24
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.
2005-03
New disinfection and sterilization methods.
2001-04-11
A chemically intelligent antimicrobial coating for urologic devices.
2000-02
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.
1998
Patents

Patents

04210711
16
04840956
16
06280923
16
06607872
16
07732486
16
08492554
16
20030220241
16
20060084679
16
20060270701
18
20110301181
16
20130072690
16
6989383
17
7553861
16
CN102923966
17
CN106167630
16
US1610391
16
US2249023
16
US2250390
16
US3639575A
16
US4391799A
16
US6180584
16

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Toxicity data
Topical as a 1:80 dilution (30 ppm ionic silver).
Route of Administration: Topical
In Vitro Use Guide
10 mkl volume of undiluted human norovirus 20% faecal suspension was mixed with 90 mkl of SDC (Silver Dihydrogen Citrate) for various contact times (15, 30, 60, 120, 300, 600 and 1800 s). At each sampling time point, 20 mkl of this solution was added to 180 mkl of 10% solution of Dey/Engley (D/E) neutralizing broth (Thermo Fisher Scientific, Waltham, MA). Samples were aliquoted and frozen at -80°C prior to nucleic acid extraction.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:14:43 GMT 2025
Edited
by admin
on Mon Mar 31 18:14:43 GMT 2025
Record UNII
95IT3W8JZE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SILVER NITRATE
EP   HSDB   INCI   MART.   MI   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
ARGENTUM NITRICUM
HPUS  
Preferred Name English
SILVER NITRATE [WHO-IP]
Common Name English
SILVER NITRATE [EP MONOGRAPH]
Common Name English
NSC-135800
Code English
TOUGHENED SILVER NITRATE [USP MONOGRAPH]
Common Name English
ARGENTI NITRAS [WHO-IP LATIN]
Common Name English
SILVER NITRATE [JAN]
Common Name English
SILVER NITRATE [MI]
Common Name English
SILVER NITRATE [HSDB]
Common Name English
ARGENTUM NITRICUM [HPUS]
Common Name English
SILVER(1+) NITRATE [WHO-IP]
Common Name English
Silver nitrate [WHO-DD]
Common Name English
SILVER NITRATE [VANDF]
Common Name English
SILVER NITRATE [MART.]
Common Name English
SILVER NITRATE [USP IMPURITY]
Common Name English
NITRIC ACID SILVER(1+) SALT
Common Name English
Classification Tree Code System Code
WHO-ATC D08AL01
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EPA PESTICIDE CODE 72503
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Food Contact Sustance Notif, (FCN No.) FCN NO. 296
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WHO-VATC QD08AL01
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WHO-ATC S01AX02
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CFR 21 CFR 310.544
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NCI_THESAURUS C28394
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
Code System Code Type Description
FDA UNII
95IT3W8JZE
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
PRIMARY
EPA CompTox
DTXSID3032042
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PRIMARY
HSDB
685
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PRIMARY
MESH
D012835
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PRIMARY
NSC
135800
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PRIMARY
CFR
21 CFR 176.300
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PRIMARY
CAS
7761-88-8
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PRIMARY
ECHA (EC/EINECS)
231-853-9
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PRIMARY
DRUG BANK
DB11080
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PRIMARY
PUBCHEM
24470
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PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SILVER NITRATE
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
PRIMARY Description: Colourless or white crystals or white cylindrical rods; odourless. Solubility: Soluble in 0.5 parts of water; soluble in ethanol (~750 g/l) TS. Category: Antiinfective agent. Storage: Silver nitrate should be kept in a tightly closed, non-metallic container, protected from light. Additional information: Even in the absence of light, Silver nitrate is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. On exposure to light and in the presence of organic matter, it becomes grey or greyish black. Definition: Silver nitrate contains not less than 99.0% and not more than 100.5% of AgNO3.
CHEBI
32130
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
PRIMARY
NCI_THESAURUS
C77057
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PRIMARY
MERCK INDEX
m9927
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PRIMARY Merck Index
EVMPD
SUB15248MIG
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PRIMARY
DAILYMED
95IT3W8JZE
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PRIMARY
RXCUI
9789
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PRIMARY RxNorm
DRUG CENTRAL
4502
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PRIMARY
WIKIPEDIA
SILVER NITRATE
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
PRIMARY
SMS_ID
100000078614
Created by admin on Mon Mar 31 18:14:43 GMT 2025 , Edited by admin on Mon Mar 31 18:14:43 GMT 2025
PRIMARY
Related Record Type Details
Structure of SILVER CATION
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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