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Details

Stereochemistry ACHIRAL
Molecular Formula Ag
Molecular Weight 107.8682
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 1

SHOW SMILES / InChI
Structure of SILVER CATION

SMILES

[Ag+]

InChI

InChIKey=FOIXSVOLVBLSDH-UHFFFAOYSA-N
InChI=1S/Ag/q+1

HIDE SMILES / InChI

Molecular Formula Ag
Molecular Weight 107.8682
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Silver Dihydrogen Citrate is a patented antimicrobial based on stabilized silver ion complex produced by a unique electrochemical process with silver and citric acid. Silver Dihydrogen Citrate provides a broad spectrum antimicrobial activity and is effective against unwanted bacteria, fungi, and viruses including pathogenic microorganisms. Its fast killing activity makes Silver Dihydrogen Citrate an effective antimicrobial for many applications. Silver has been used for centuries for its antimicrobial properties. In order for silver to be effective in killing microorganisms, it must be in an ionic form. Silver Dihydrogen Citrate is a complex of one silver ion weakly bound to one citrate ion having the molecular complex AgC6H7O7. Silver Dihydrogen Citrate provides a stabilized form of silver ion in an organic acid (citric acid). The bioavailability of the ions allows for Silver Dihydrogen Citrate to be rapidly effective against a broad spectrum of bacteria, viruses, and fungi. Silver ions are highly attracted to sulfur-containing thiol groups found in metabolic and structural proteins bound to the membrane surface. Silver Dihydrogen Citrate targets these critical proteins and destroys their structure. This disruption of the organisms’ membrane function and integrity lyses the membrane and the organism dies.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.
1998
A chemically intelligent antimicrobial coating for urologic devices.
2000 Feb
New disinfection and sterilization methods.
2001 Mar-Apr
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.
2005 Mar
Photocatalytic degradation of pathogenic bacteria with AgI/TiO2 under visible light irradiation.
2007 Apr 24
Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli.
2008 Apr
Topical antimicrobials for burn wound infections.
2010 Jun
Development of silica-coated silver iodide nanoparticles and their biodistribution.
2012 Dec
Cleaning and decontamination efficacy of wiping cloths and silver dihydrogen citrate on food contact surfaces.
2012 Jul
A novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione.
2014 Apr 22
UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.
2016 Jan
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care.
2016 Mar-Apr
Directional growth of Ag nanorod from polymeric silver cyanide: A potential substrate for concentration dependent SERS signal enhancement leading to melamine detection.
2017 Aug 5
The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.
2017 May 8
Patents

Sample Use Guides

In Vitro Use Guide
Antibacterial and antifungal efficacies of the prepared AgBr and Ag NPs were tested using the standard dilution method which enables to determine the minimum inhibitory concentrations (MICs) of the tested samples necessary to inhibit the growth of the bacterial strains and yeasts. For the purpose of antimicrobial testing, aqueous dispersions of AgBr and Ag NPs at the silver concentration equal to 108 mg/L for AgBr colloid and 89.6 mg/L for Ag dispersions were used. The testing was carried out in microtitration plates where the tested samples were diluted by the culture medium (Mueller Hinton Broth, Difco, France) in a geometric progression from 2 to 128 times. Culture medium was inoculated with the tested bacteria or yeast at a concentration of 10^5 to 10^6 CFU/mL. After 24-h incubation at 37°C, the MICs of AgBr and Ag nanoparticles were read as the lowest concentrations of the tested substance inhibiting the visible growth of microorganisms.
Substance Class Chemical
Created
by admin
on Tue Oct 22 19:45:01 UTC 2019
Edited
by admin
on Tue Oct 22 19:45:01 UTC 2019
Record UNII
57N7B0K90A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SILVER CATION
Common Name English
SILVER, ION (AG1+)
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 72500
Created by admin on Tue Oct 22 19:45:03 UTC 2019 , Edited by admin on Tue Oct 22 19:45:03 UTC 2019
Code System Code Type Description
CAS
14701-21-4
Created by admin on Tue Oct 22 19:45:03 UTC 2019 , Edited by admin on Tue Oct 22 19:45:03 UTC 2019
PRIMARY
RXCUI
1358876
Created by admin on Tue Oct 22 19:45:03 UTC 2019 , Edited by admin on Tue Oct 22 19:45:03 UTC 2019
PRIMARY RxNorm
PUBCHEM
104755
Created by admin on Tue Oct 22 19:45:03 UTC 2019 , Edited by admin on Tue Oct 22 19:45:03 UTC 2019
PRIMARY
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