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Details

Stereochemistry ACHIRAL
Molecular Formula Ag.NO3
Molecular Weight 169.8731
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILVER NITRATE

SMILES

[Ag+].[O-][N+]([O-])=O

InChI

InChIKey=SQGYOTSLMSWVJD-UHFFFAOYSA-N
InChI=1S/Ag.NO3/c;2-1(3)4/q+1;-1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/monograph/silver-nitrate.html | https://www.ncbi.nlm.nih.gov/pubmed/18245232

Silver iodide is an inorganic compound with the formula AgI. It is used as a photosensitive agent in photography, as a local antiseptic, as a chemical intermediate, and in cloud seeding for rain-making. The major hazards encountered in the use and handling of silver iodide stem from its toxicologic properties. Effects from exposure may include skin rashes, conjunctivitis, argyria (a permanent ashen-gray discoloration of skin, conjunctiva, and internal organs), headache, fever, hypersensitivity, laryngitis, and bronchitis.

Originator

Orisheva, R.M.|Nechepurenko, Yu.V.|Sokolov, V.G.
16
Sources: Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk, Issue 2, Pages 69-73, Journal, 1990https://www.ncbi.nlm.nih.gov/pubmed/20429870
Curator's Comment: The medical uses of silver date back to at least the time of Hippocrates

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Substrate
661
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Approved
8429
Advantage Arrest Silver Diamine Fluoride

Approved Use

Unknown
Primary
Phase I
428
Unknown

Approved Use

Unknown
Curative
Not Provided
504
Unknown

Approved Use

Unknown
Curative
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Not Provided
504
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Primary
Not Provided
504
Colloidal silver iodide

Approved Use

Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Palliative
Approved
8429
Unknown

Approved Use

Antiseptic Wound Cauterization
Primary
Approved
8429
Unknown

Approved Use

Prophylaxis of gonococcal ophthalmia neonatorum. AAP recommends use of topical silver nitrate, povidone-iodine, or possibly erythromycin for prophylaxis of nongonococcal nonchlamydial conjunctivitis in neonates, ideally administered shortly after birth.
PubMed

PubMed

TitleDatePubMed
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.
1998
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.
2005 Mar
Photocatalytic degradation of pathogenic bacteria with AgI/TiO2 under visible light irradiation.
2007 Apr 24
Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli.
2008 Apr
Topical antimicrobials for burn wound infections.
2010 Jun
Development of silica-coated silver iodide nanoparticles and their biodistribution.
2012 Dec
Cleaning and decontamination efficacy of wiping cloths and silver dihydrogen citrate on food contact surfaces.
2012 Jul
UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.
2016 Jan
Patents

Patents

04210711
16
04840956
16
06280923
16
06607872
16
07732486
16
08492554
16
20030220241
16
20060084679
16
20060270701
18
20110301181
16
20130072690
16
6989383
17
7553861
16
CN102923966
17
CN106167630
16
US1610391
16
US2249023
16
US2250390
16
US3639575A
16
US4391799A
16
US6180584
16

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Toxicity data
Topical as a 1:80 dilution (30 ppm ionic silver).
Route of Administration: Topical
In Vitro Use Guide
10 mkl volume of undiluted human norovirus 20% faecal suspension was mixed with 90 mkl of SDC (Silver Dihydrogen Citrate) for various contact times (15, 30, 60, 120, 300, 600 and 1800 s). At each sampling time point, 20 mkl of this solution was added to 180 mkl of 10% solution of Dey/Engley (D/E) neutralizing broth (Thermo Fisher Scientific, Waltham, MA). Samples were aliquoted and frozen at -80°C prior to nucleic acid extraction.
Name Type Language
SILVER NITRATE
EP   HSDB   INCI   MART.   MI   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
SILVER NITRATE [WHO-IP]
Common Name English
SILVER NITRATE [EP MONOGRAPH]
Common Name English
NSC-135800
Code English
TOUGHENED SILVER NITRATE [USP MONOGRAPH]
Common Name English
ARGENTI NITRAS [WHO-IP LATIN]
Common Name English
SILVER NITRATE [JAN]
Common Name English
SILVER NITRATE [MI]
Common Name English
SILVER NITRATE [HSDB]
Common Name English
ARGENTUM NITRICUM [HPUS]
Common Name English
ARGENTUM NITRICUM
HPUS  
Common Name English
SILVER(1+) NITRATE [WHO-IP]
Common Name English
Silver nitrate [WHO-DD]
Common Name English
SILVER NITRATE [VANDF]
Common Name English
SILVER NITRATE [INCI]
Common Name English
SILVER NITRATE [MART.]
Common Name English
SILVER NITRATE [USP IMPURITY]
Common Name English
NITRIC ACID SILVER(1+) SALT
Common Name English
Classification Tree Code System Code
WHO-ATC D08AL01
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
EPA PESTICIDE CODE 72503
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 296
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
WHO-VATC QD08AL01
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
WHO-ATC S01AX02
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
CFR 21 CFR 310.544
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
Code System Code Type Description
FDA UNII
95IT3W8JZE
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
EPA CompTox
DTXSID3032042
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
HSDB
685
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
MESH
D012835
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
NSC
135800
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
CFR
21 CFR 176.300
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
CAS
7761-88-8
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-853-9
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
DRUG BANK
DB11080
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
PUBCHEM
24470
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SILVER NITRATE
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY Description: Colourless or white crystals or white cylindrical rods; odourless. Solubility: Soluble in 0.5 parts of water; soluble in ethanol (~750 g/l) TS. Category: Antiinfective agent. Storage: Silver nitrate should be kept in a tightly closed, non-metallic container, protected from light. Additional information: Even in the absence of light, Silver nitrate is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. On exposure to light and in the presence of organic matter, it becomes grey or greyish black. Definition: Silver nitrate contains not less than 99.0% and not more than 100.5% of AgNO3.
CHEBI
32130
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
NCI_THESAURUS
C77057
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
MERCK INDEX
m9927
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY Merck Index
EVMPD
SUB15248MIG
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
DAILYMED
95IT3W8JZE
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
RXCUI
9789
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
4502
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
WIKIPEDIA
SILVER NITRATE
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
SMS_ID
100000078614
Created by admin on Fri Dec 15 15:57:46 GMT 2023 , Edited by admin on Fri Dec 15 15:57:46 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of SILVER CATION
SUBSTANCE RECORD
Structure of SILVER NITRATE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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