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Restrict the search for
uracil mustard
to a specific field?
Status:
Possibly Marketed Outside US
Source:
Mustargen by Gilman, A.|Goodman, L.S.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Mechlorethamine Oxide was approved by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. A biologic alkylating agent exerts its cytotoxic effects by forming DNA adducts and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. Mechlorethamine Oxide is an antineoplastic agent used to treat Hodgkin desease and Lymphoma. Known under the brand names of Mustargen and Valchlor in USA. The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL.
Status:
Possibly Marketed Outside US
Source:
Mitarson by Asta-Werke [W. Germany]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Defosfamide (Mitarson) was developed as antineoplastic agent. Mitarson and radioactive gold were used in some patients with poor results. The most serious complication resulting from therapy was hemorrhagic cystitis.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Trichlormethine is a nitrogen mustard vesicant that has application in chemical warfare and has been used as a cytostatic alkylating agent in leukemia and lymphoma therapy. Trichlormethine was tested for carcinogenicity by subcutaneous injection in mice and rats. The study in mice was inadequate for evaluation. In rats, trichlormethine induced a high incidence of sarcomas (mostly spindle-cell type) in animals of each sex at the site of subcutaneous injection, as well as a few intestinal adenocarcinomas; neither tumor type was seen in controls. Trichlormethine caused vomiting, anorexia and blood-containing feces in dogs a few hours after a single intravenous injection of 1 mg/kg BW. Decreased peripheral lymphocyte counts were observed in rabbits injected intravenously and in mice injected subcutaneously with trichlormethine. Trichlormethine was tested for carcinogenicity by subcutaneous injection in mice and rats. ln rats, trichlormethine induced a high incidence of sarcomas (mostly spindle-cell type) in animals of each sex at the site of subcutaneous injection, as well as a few intestinal adenocarcinomas; neither tumor type was seen in controls. Trichlormethine is possibly carcinogenic to humans (Group 2B).
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Edoxudine (5-ethyl-2'-deoxyuridine), an antiviral drug, has been clinically studied against the recurrent genital herpes.
Status:
Possibly Marketed Outside US
Source:
Mostarina by Abello [Spain]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Prednimustine is chlorambucil ester of prednisolone. Prednimustine is a cytostatic agent. Prednimustine is active against a wide variety of experimental tumors both in vivo and in vitro. In many of these tumor systems, prednimustine exhibits distinct advantages over a mixture of its constituents, chlorambucil and prednisolone. In vitro, a higher cell kill is obtained, and in vivo, at doses that are equally effective, prednimustine is less toxic. It has been used in the treatment of various malignancies, including chronic lymphatic leukaemia and non-Hodgkin's lymphomas. It has also been tested for use in the treatment of breast cancer
Status:
Possibly Marketed Outside US
Source:
Potassium orotate by Nieper, H.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Potassium Orotate is a non-steroidal anabolic preparation with regenerating, diuretic effect. Potassium Orotate improves appetite, cardiac glycosides tolerance, stimulates regenerative and reparative processes of metabolism. Orotic acid is one of precursors the pyrimidine nucleotides which are a part of nucleic acids which participate in synthesis of protein molecules. In this regard potassium orotate is applied as substance of anabolic action at disturbances of protein metabolism, first of all at disturbance of albumin function of a liver, at the dystrophic changes in a myocardium which developed as owing to pathological process (a myocarditis, myocardial infarction), and as a result of a physical overstrain in sport as the general stimulators of metabolic processes.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Uracil is a common and naturally occurring pyrimidine derivative, one of the four nucleobases in the nucleic acid of RNA In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by it’s methylated form -- thymine. Originally discovered in 1900 by Alberto Ascoli, it was isolated by hydrolysis of yeast nuclein;[4] it was also found in bovine thymus and spleen, herring sperm, and wheat germ. It is a planar, unsaturated compound that has the ability to absorb light. Uracil readily undergoes regular reactions including oxidation, nitration, and alkylation. While in the presence of phenol (PhOH) and sodium hypochlorite (NaOCl), uracil can be visualized in ultraviolet light. Uracil also has the capability to react with elemental halogens because of the presence of more than one strongly electron donating group. Uracil readily undergoes addition to ribose sugars and phosphates to partake in synthesis and further reactions in the body. Uracil becomes uridine, uridine monophosphate (UMP), uridine diphosphate (UDP), uridine triphosphate (UTP), and uridine diphosphate glucose (UDP-glucose). Each one of these molecules is synthesized in the body and has specific functions. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for reactions in the human body and in plants. Uracil can be used for drug delivery and as a pharmaceutical. When elemental fluorine is reacted with uracil, 5-fluorouracil is produced. 5-Fluorouracil is an anticancer drug (antimetabolite) used to masquerade as uracil during the nucleic acid replication process. In combination with Tegafur, uracil used as a chemotherapy drug (called UFT or UFUR) used in the treatment of cancer, primarily bowel cancer. UFT is an anticancer medication composed of a fixed molar ratio (1:4) of tegafur and uracil to be administered with calcium folinate.
Status:
Withdrawn
Source:
Chlornaphazine
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Chlornaphazine was developed as a drug to treat Hodgkin's disease. However this compound caused bladder tumors, it was manifested human carcinogen, that is why its use was discontinued.
Status:
US Approved Allergenic Extract
(1972)
Source:
BLA102192
(1972)
Source URL:
First approved in 1972
Source:
BLA102192
Source URL:
Class:
MIXTURE
Status:
Possibly Marketed Outside US
Source:
kanoSAN by sanPharma GmbH
(2018)
Source URL:
First approved in 1994
Source:
Sweat by JACKS MFG INC
Source URL:
Class:
MIXTURE
