CHLORNAPHAZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15Cl2N
Molecular Weight	268.182
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CHLORNAPHAZINE

Structure Search

SMILES

ClCCN(CCCl)C1=CC=C2C=CC=CC2=C1

InChI

InChIKey=XCDXSSFOJZZGQC-UHFFFAOYSA-N

InChI=1S/C14H15Cl2N/c15-7-9-17(10-8-16)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11H,7-10H2

HIDE SMILES / InChI

Molecular Formula	C14H15Cl2N
Molecular Weight	268.182
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1145787 | https://www.ncbi.nlm.nih.gov/pubmed/13180246 | https://www.ncbi.nlm.nih.gov/pubmed/14171978

Chlornaphazine was developed as a drug to treat Hodgkin's disease. However this compound caused bladder tumors, it was manifested human carcinogen, that is why its use was discontinued.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Chlornaphazine and chlorambucil induce dominant lethal mutations in male mice.	2003 Mar	12644184
Epidemiology of urinary bladder cancer: from tumor development to patient's death.	2007 Jun	17530260

Patents

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:32:52 GMT 2023` Edited by `admin` on `Fri Dec 15 16:32:52 GMT 2023`
Record UNII	U46E473275
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHLORNAPHAZINE

Official Name

English

CHLORNAPHAZINE [IARC]

Common Name

English

R 48

Code

English

CHLORNAPHAZINE [MI]

Common Name

English

CB-1048

Code

English

CHLORNAPHAZINE [HSDB]

Common Name

English

chlornaphazine [INN]

Common Name

English

NSC-62209

Code

English

CB 1048

Code

English

N,N-BIS(2-CHLOROETHYL)-2-NAPHTHYLAMINE

Systematic Name

English

R-48

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C697

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

Code System Code Type Description

ChEMBL

CHEMBL2107519

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

PRIMARY

ECHA (EC/EINECS)

207-785-0

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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NSC

62209

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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DRUG CENTRAL

604

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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MERCK INDEX

m3378

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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Merck Index

EPA CompTox

DTXSID3060087

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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FDA UNII

U46E473275

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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SMS_ID

100000081846

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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WIKIPEDIA

CHLORNAPHAZINE

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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INN

1314

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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EVMPD

SUB06189MIG

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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NCI_THESAURUS

C1047

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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PUBCHEM

10307

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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CAS

494-03-1

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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HSDB

2745

Created by admin on Fri Dec 15 16:32:52 GMT 2023 , Edited by admin on Fri Dec 15 16:32:52 GMT 2023

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Related Record Type Details


					U46E473275

ACTIVE MOIETY