EDOXUDINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H16N2O5
Molecular Weight	256.2551
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

InChIKey=XACKNLSZYYIACO-DJLDLDEBSA-N

InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1894930 | https://www.ncbi.nlm.nih.gov/pubmed/14743269

Edoxudine (5-ethyl-2'-deoxyuridine), an antiviral drug, has been clinically studied against the recurrent genital herpes.

Approval Year

PubMed

Title	Date	PubMed
5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.	1978 Mar	233730
Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.	1979 Nov	526011
5-substituted deoxyuridines--structural requirements for antiviral activity against herpes simplex virus types 1 and 2 and possible biochemical basis for relative potency.	1984 Jun	6089658
Synthesis and antitumor and antiviral properties of 5-alkyl-2'-deoxyuridines, 3',5'-cyclic monophosphates, and neutral cyclic triesters.	1986 Apr	3959027
Synthesis and antiviral activity of the carbocyclic analogues of 5-ethyl-2'-deoxyuridine and of 5-ethynyl-2'-deoxyuridine.	1986 Jan	3001308
Incorporation and metabolism of 2'-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells.	1988 Dec 1	2852483
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.	2003 Aug 4	12898625
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.	2003 May-Aug	14565282
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.	2003 Sep 15	12941330
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods.	2006 Feb 15	16290929
Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.	2010 Nov 15	20863701

Patents

Sample Use Guides

In Vivo Use Guide

topical edoxudine 3.0% cream

Route of Administration: Topical

Name

Type

Language

EDOXUDINE

Official Name

English

EDU

Common Name

English

URIDINE, 2'-DEOXY-5-ETHYL-

Systematic Name

English

2'-DEOXY-5-ETHYLURIDINE

Systematic Name

English

ORF-15817

Code

English

EDOXUDINE [USAN]

Common Name

English

EUDR

Common Name

English

Edoxudine [WHO-DD]

Common Name

English

5-ETHYL-3-(2'-DEOXYRIBOSYL)URACIL

Common Name

English

EDOXUDINE [MI]

Common Name

English

ORF 15817

Code

English

RWJ-15817

Code

English

RWJ 15817

Code

English

5-ETHYL-2'-DEOXYURIDINE

Systematic Name

English

NSC-758405

Code

English

edoxudine [INN]

Common Name

English

EDOXUDINE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QD06BB09