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Status:
Investigational
Source:
INN:ramifenazone [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Ramifenazone is pyrazolone derivative with analgesic, antipyretic, and anti-inflammatory activity. In preclinical studies, Ramifenazone shows potent inhibition of prostaglandin production, carrageenan edema, and yeast fever.
Status:
Investigational
Source:
INN:alphamethadol [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Alphamethadol is a synthetic opioid analgesic. Alphamethadol is composed of two isomers itself, L-α-methadol, and D-α-methadol. L-α-methadol is an important active metabolite of levacetylmethadol (LAAM), a medication therapy for individuals addicted to opiates that provides an alternative to methadone. Isomers of Alphamethadol bind to and activate the μ-opioid receptor; they are active as opioid analgesics.
Class (Stereo):
CHEMICAL (RACEMIC)
Metiprenaline was developed as a bronchodilator. Information about the current use of this compound is not available.
Status:
Investigational
Source:
NCT00960557: Phase 1 Interventional Completed Neoplasm Metastasis
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Oxi0-4503 (now known as combretastatin A1 phosphate), a diphosphate prodrug of combretastatin A1, was developed by Mateon therapeutics as a second-generation, dual-mechanism vascular disrupting agent from the combretastatin family. On November 21, 2012, Oxi-4503 has been granted orphan designation by the US Food and Drug Administration for the treatment of acute myelogenous leukemia. It is known that the orphan drug designation qualifies a company for several benefits, including the potential for market exclusivity, development grants, and tax credits. Oxi0-4503 is currently participating in phase I/II clinical trial the treatment of patients with acute myelogenous leukemia or myelodysplastic syndrome. In addition, phase I clinical trial was successfully completed where was studied the safety of Oxi0-4503 in patients with advanced solid tumors.
Status:
Investigational
Source:
INN:asalhydromorphone [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class (Stereo):
CHEMICAL (UNKNOWN)
Clazolam (isoquinazepon) is a fuzed benzodiazepine drug developed by Sandoz in the 1960s. The drug is claimed to have anxiolytic properties, which are manifested in a reduction of cramping, antagonism of amphetamine, and by inhibition of spinal reflexes.
Status:
Investigational
Source:
NCT00555074: Phase 2 Interventional Completed Obesity
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Tungstic acid is a fairly strong acid, it catalyzes the oxidation by hydrogen peroxide of alkenes to the corresponding epoxides. Tungstic acid is widely used in the production of tungsten metal, alloys, and is used as a mordant for textiles and plastics. Tungstic acid has been reported to
rapidly precipitate the quaternary ammonium cations in cholinergic nerve terminals, such as ACh or choline. Also, tungsten dietary supplementation has successfully
been used to reduce xanthine oxide (XO) activity,
resulting in decreased gastrointestinal (GI) mucosal damage because of lowered XO activity. Tungstic acid has been shown to effectively antagonize stress-induced gastric ulcers, possibly by decreasing motility and mass cell degranulation. Tungstic acid gel has been used as an epileptogenic agent since 1960. Epilepsy produced by this agent is characterized by good localization, short latency and limited duration. It is effective in cerebral cortex, brain stem and spinal cord.
Status:
Investigational
Source:
NCT03598699: Phase 2 Interventional Completed Dry Eye
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
INN:deanol aceglumate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Deanol is a chemical compound that is involved in the biosynthesis of the neurotransmitter acetylcholine. Deanol aceglumate is marketed in Russia as a hepatoprotector and neurometabolic stimulator for the treatment of asthenic and astheno-depressive disorders, neuroleptic syndrome, alcohol withdrawal syndrome, neurotic and neurosis-like disorders, acute and chronic hepatitis, cirrhosis of the liver, cholestasis, fatty liver dystrophy of various genesis.
Status:
Investigational
Source:
INN:deanol aceglumate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Deanol is a chemical compound that is involved in the biosynthesis of the neurotransmitter acetylcholine. Deanol aceglumate is marketed in Russia as a hepatoprotector and neurometabolic stimulator for the treatment of asthenic and astheno-depressive disorders, neuroleptic syndrome, alcohol withdrawal syndrome, neurotic and neurosis-like disorders, acute and chronic hepatitis, cirrhosis of the liver, cholestasis, fatty liver dystrophy of various genesis.