Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H29NO.ClH |
| Molecular Weight | 347.922 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CC[C@@H](O)C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI
InChIKey=GMNBUMFCZAZBQG-OGPPPPIKSA-N
InChI=1S/C21H29NO.ClH/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,17,20,23H,5,16H2,1-4H3;1H/t17-,20-;/m1./s1
| Molecular Formula | C21H29NO |
| Molecular Weight | 311.4611 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Alphamethadol is a synthetic opioid analgesic. Alphamethadol is composed of two isomers itself, L-α-methadol, and D-α-methadol. L-α-methadol is an important active metabolite of levacetylmethadol (LAAM), a medication therapy for individuals addicted to opiates that provides an alternative to methadone. Isomers of Alphamethadol bind to and activate the μ-opioid receptor; they are active as opioid analgesics.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Carbon-13 nuclear magnetic resonance study of the alpha- and beta- isomers of methadol and acetylmethadol hydrochlorides. | 1978 |
|
| The binding of the optical isomers of methadone, alpha-methadol, alpha-acetylmethadol and their N-demethylated derivatives to the opiate receptors of rat brain. | 1976-08 |
|
| Crystal structures of analgesics. Hydrochlorides of (minus)-isomethadone, alpha-methadol, and alpha-methadyl acetate. | 1974-10 |
|
| [Chromatographic separation methods for methadone and the reduction products alpha and beta-methadol]. | 1970-02 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:24:11 GMT 2025
by
admin
on
Mon Mar 31 23:24:11 GMT 2025
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| Record UNII |
396F4076KY
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| Record Status |
Validated (UNII)
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| Record Version |
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49570-63-0
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396F4076KY
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admin on Mon Mar 31 23:24:11 GMT 2025 , Edited by admin on Mon Mar 31 23:24:11 GMT 2025
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